{"id":"W4416982112","doi":"10.5267/j.ccl.2025.9.003","title":"Design, synthesis, and antidiabetic evaluation of novel 1,3-di(1,3,4-oxadiazol-2-yl)benzene derivatives as potent pancreatic α-amylase inhibitors: In vitro and in silico approaches","year":2025,"lang":"","type":"article","venue":"Current Chemistry Letters","topic":"Natural Antidiabetic Agents Studies","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"In silico; In vitro; Docking (animal); IC50; Small molecule; Molecular model; Potency; Enzyme","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001619235,0.00075501,0.001425996,0.0003947433,0.0001200654,0.00005203308,0.0002156391,0.0002616163,0.00002558044],"category_scores_gemma":[0.00253748,0.0007292374,0.0001272771,0.000884548,0.0008879603,0.0001798076,0.0003341124,0.00074305,0.000001610749],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005437479,"about_ca_system_score_gemma":0.000383842,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004455264,"about_ca_topic_score_gemma":0.000001388282,"domain_scores_codex":[0.9955468,0.0003696964,0.0013153,0.00115326,0.0008434888,0.0007714222],"domain_scores_gemma":[0.9977425,0.0009436417,0.0004679087,0.0004692164,0.0001772659,0.000199447],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000446101,0.001153146,0.03275491,0.005141085,0.0003224737,0.00001119161,0.001034041,0.0002378823,0.9272002,0.000002301644,0.00004340847,0.03165327],"study_design_scores_gemma":[0.005619486,0.00001959865,0.05200863,0.007169476,0.00125775,0.000009426666,0.00146781,0.01036071,0.9214588,0.00007473412,0.000006177534,0.0005473536],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9356533,0.05836213,0.0002225781,0.003635741,0.0002480953,0.001767066,0.00003503652,0.00001934361,0.00005670695],"genre_scores_gemma":[0.996105,0.00292316,0.000392636,0.00008425023,0.0001242876,0.0002854088,0.00003984302,0.00003687568,0.000008522741],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06045172,"threshold_uncertainty_score":0.9995159,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05601511104130206,"score_gpt":0.2918385785567221,"score_spread":0.2358234675154201,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}