{"id":"W4416982112","doi":"10.5267/j.ccl.2025.9.003","title":"Design, synthesis, and antidiabetic evaluation of novel 1,3-di(1,3,4-oxadiazol-2-yl)benzene derivatives as potent pancreatic α-amylase inhibitors: In vitro and in silico approaches","year":2025,"lang":"","type":"article","venue":"Current Chemistry Letters","topic":"Natural Antidiabetic Agents Studies","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"In silico; In vitro; Docking (animal); IC50; Small molecule; Molecular model; Potency; Enzyme","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001514631,0.000353745,0.0003286253,0.0002154394,0.0001193676,0.0002634138,0.0003069583,0.0002008515,0.001557854],"category_scores_gemma":[0.000107323,0.0001626075,0.0001989627,0.0002905656,0.0001147683,0.0002358089,0.0001721336,0.0003636731,0.0003524012],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002440354,"about_ca_system_score_gemma":0.0002538759,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005676575,"about_ca_topic_score_gemma":0.001694411,"domain_scores_codex":[0.9999491,0.000009897492,0.000004568794,0.00001049011,0.00001328031,0.00001269497],"domain_scores_gemma":[0.9999533,0.000004055422,0.0000157503,0.000003262553,0.000009560816,0.0000141036],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000340266,0.0004012532,0.000296039,0.0007735357,0.00003648111,0.0002659341,0.00005684713,0.003102859,0.9785355,0.0008386115,0.0004237337,0.01492888],"study_design_scores_gemma":[0.0003457534,0.007316755,0.00294226,0.00006099034,0.0001251124,0.000499109,0.00005501008,0.006022936,0.9593501,0.0001697845,0.02306429,0.00004788922],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9434947,0.02790455,0.01792368,0.0004845826,0.0001377837,0.0004771632,0.001758436,0.0002385083,0.007580501],"genre_scores_gemma":[0.9643798,0.01548544,0.01365453,0.0001800032,0.00002302653,0.0001910018,0.0009749642,0.00002055489,0.005090655],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001557854,"threshold_uncertainty_score":0.005211532,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05601511104130206,"score_gpt":0.2918385785567221,"score_spread":0.2358234675154201,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}