{"id":"W4416983134","doi":"10.1080/07357907.2025.2596854","title":"Breast Cancer Susceptibility: Meta-Analysis of Cytochrome P450 2C19 ( <i>CYP2C19</i> ) and Estrogen Receptor-1 ( <i>ESR1</i> ) Genetic Variants","year":2025,"lang":"en","type":"article","venue":"Cancer Investigation","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Genetic variants; Breast cancer; Estrogen; Cytochrome P450; CYP2C19; Estrogen receptor; Genetic variation","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000220049,0.0002481131,0.0005735323,0.0001648862,0.00009276775,0.00002818707,0.0001732201,0.0002637938,0.0001194768],"category_scores_gemma":[0.00002663976,0.0002173504,0.0003711059,0.0007804639,0.000294674,0.00001179356,0.00009606698,0.0001273494,0.000001873518],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004976214,"about_ca_system_score_gemma":0.0002914736,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006834842,"about_ca_topic_score_gemma":0.0001889321,"domain_scores_codex":[0.9984377,0.0001674177,0.0003945985,0.0005839991,0.0001743017,0.0002420055],"domain_scores_gemma":[0.9989772,0.00002617518,0.0002095428,0.000451184,0.0001996745,0.0001362436],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007234974,0.00003313213,0.02562368,0.00008650291,0.0332328,9.046623e-7,0.00005852092,0.001837652,0.9352827,0.0001536138,0.002318878,0.001299244],"study_design_scores_gemma":[0.001212381,0.000210265,0.1001602,0.00005887891,0.1268215,0.0000132561,0.00005478949,0.001425584,0.7665085,0.000468884,0.002384292,0.000681535],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9737054,0.02398991,0.0003276994,0.0009345414,0.0001115136,0.00036696,0.0004088556,0.0000191441,0.000135958],"genre_scores_gemma":[0.9958709,0.001558885,0.0005672655,0.001097415,0.00008674017,0.0001940556,0.0002164442,0.0000227764,0.0003854834],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1687742,"threshold_uncertainty_score":0.8863294,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01827648228667883,"score_gpt":0.2783405185910849,"score_spread":0.2600640363044061,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}