{"id":"W4416983134","doi":"10.1080/07357907.2025.2596854","title":"Breast Cancer Susceptibility: Meta-Analysis of Cytochrome P450 2C19 ( <i>CYP2C19</i> ) and Estrogen Receptor-1 ( <i>ESR1</i> ) Genetic Variants","year":2025,"lang":"en","type":"article","venue":"Cancer Investigation","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Genetic variants; Breast cancer; Estrogen; Cytochrome P450; CYP2C19; Estrogen receptor; Genetic variation","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01468153,0.002354506,0.008176537,0.003742985,0.0006843008,0.002758265,0.001791193,0.001508523,0.004326947],"category_scores_gemma":[0.02839783,0.001005379,0.03607262,0.005639007,0.000546132,0.001051465,0.00127444,0.001657388,0.000361689],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001240317,"about_ca_system_score_gemma":0.001924232,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008715672,"about_ca_topic_score_gemma":0.01135416,"domain_scores_codex":[0.989069,0.006769703,0.001452304,0.001639397,0.0006969778,0.0003726511],"domain_scores_gemma":[0.9801988,0.0158379,0.001475053,0.001446372,0.0007853762,0.0002564377],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.002785593,0.00002017782,0.02947891,0.02621928,0.9290813,0.0001875516,0.00004691313,0.001838707,0.0006299945,0.000217957,0.001170823,0.008322822],"study_design_scores_gemma":[0.0004603356,0.0001911751,0.01544858,0.002068902,0.9778594,0.0001454615,0.00003230504,0.0008926644,0.0002898714,0.0005165082,0.00207678,0.0000179847],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.05920741,0.9250968,0.008086712,0.001547521,0.0006459998,0.0002330999,0.003651715,0.0002516276,0.00127914],"genre_scores_gemma":[0.8497205,0.1384216,0.006415877,0.001079882,0.0004329527,0.0004789444,0.002415362,0.0001454364,0.0008894803],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01468153,"threshold_uncertainty_score":0.07764429,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01827648228667883,"score_gpt":0.2783405185910849,"score_spread":0.2600640363044061,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}