{"id":"W4416987428","doi":"10.1016/j.bmc.2025.118493","title":"In vitro and in vivo activity profiles of broad-spectrum bacterial ATP synthase inhibitors","year":2025,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"ATP Synthase and ATPases Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Fonds de recherche du Québec – Nature et technologies; Jet Propulsion Laboratory; Canadian Institutes of Health Research; Québec Consortium for Drug Discovery; Mitacs; Natural Sciences and Engineering Research Council of Canada; Cystic Fibrosis Canada; Université de Sherbrooke","keywords":"Staphylococcus aureus; In vitro; Acinetobacter baumannii; In vivo; Escherichia coli; Antibacterial activity; Linker; Bacteria; Indole test","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001951675,0.0004032791,0.0003774369,0.0003144628,0.00008373492,0.0002154786,0.0002034547,0.0002428174,0.001200061],"category_scores_gemma":[0.0002014771,0.0001290395,0.0002222008,0.0002271811,0.0001440729,0.0001702905,0.00009711309,0.0005310291,0.000231367],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001399955,"about_ca_system_score_gemma":0.0001713958,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003992763,"about_ca_topic_score_gemma":0.0007020774,"domain_scores_codex":[0.9998904,0.00003176204,0.000009888005,0.00002021359,0.00001824701,0.00002939148],"domain_scores_gemma":[0.9998511,0.00003185012,0.0000349568,0.00001309167,0.00001881874,0.00005019613],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003083439,0.001363358,0.000709263,0.00009186957,0.00004462781,0.00006765805,0.00002410201,0.001015867,0.9839357,0.00004590398,0.0002240058,0.009394314],"study_design_scores_gemma":[0.0003764358,0.05861977,0.01522301,0.00002512538,0.0001789613,0.0003298889,0.00007530562,0.003011483,0.9182633,0.00007102449,0.003802193,0.0000234369],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930803,0.003923605,0.0008863623,0.00006773839,0.00003840718,0.00004467821,0.0007535146,0.00005927351,0.001146249],"genre_scores_gemma":[0.9926999,0.003075477,0.0007523551,0.00009076329,0.00002902674,0.00005053227,0.001577085,0.00001745621,0.001707556],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001200061,"threshold_uncertainty_score":0.004014552,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007240067564513894,"score_gpt":0.2686586432981581,"score_spread":0.2614185757336442,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}