{"id":"W4416990044","doi":"10.1007/s40262-025-01602-4","title":"Guidance for External Evaluation and Selection of Population Pharmacokinetic Models for Precision Dosing","year":2025,"lang":"en","type":"article","venue":"Clinical Pharmacokinetics","topic":"Statistical Methods in Clinical Trials","field":"Mathematics","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"Fonds de Recherche du Québec - Santé","keywords":"Dosing; Selection (genetic algorithm); Population; Key (lock); Model selection; Clinical trial","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.0101397,0.0002208762,0.0007445579,0.0001264376,0.0001071793,0.00003261564,0.0002097094,0.0002338779,0.00005022868],"category_scores_gemma":[0.06352926,0.0002096125,0.0002623373,0.0002553589,0.0001457696,0.0001067995,0.00008594224,0.0002344201,4.130912e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006283191,"about_ca_system_score_gemma":0.00006758883,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002978844,"about_ca_topic_score_gemma":0.000001066876,"domain_scores_codex":[0.9955491,0.0008651909,0.002344091,0.0005709361,0.0003975756,0.0002730639],"domain_scores_gemma":[0.9439886,0.05402952,0.0007159127,0.0002040386,0.0009522591,0.0001096171],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.003064109,0.0007431089,0.002254671,0.001496581,0.0002357535,2.073648e-7,0.00003486425,0.004144603,0.01392503,0.05308842,0.006874636,0.914138],"study_design_scores_gemma":[0.004001602,0.0002023159,0.001716856,0.0002299502,0.0007115264,4.354696e-7,0.000002405932,0.4459723,0.004402216,0.5423589,0.0002914675,0.0001100277],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.08364405,0.0003202528,0.9107057,0.0002330826,0.001481607,0.003243953,0.00009115173,0.00005461232,0.0002255495],"genre_scores_gemma":[0.3680148,0.0001664365,0.6307947,0.0002014488,0.0004444253,0.0002374501,0.000006369785,0.00002886153,0.0001054938],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.914028,"threshold_uncertainty_score":0.944359,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.6026922687554581,"score_gpt":0.6569799012189769,"score_spread":0.05428763246351875,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}