{"id":"W4416994043","doi":"10.1128/msystems.01507-25","title":"Co-culture metabolomics: a powerful tool for uncovering host-pathogen phenotypes driving <i>Burkholderia</i> infections","year":2025,"lang":"en","type":"article","venue":"mSystems","topic":"Burkholderia infections and melioidosis","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Metabolomics; Metabolic pathway; Phenotype; Pathogen; Peptidoglycan; Metabolome; Nicotinamide adenine dinucleotide; Citric acid cycle; Intracellular; Glycolysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003877087,0.0002757338,0.0005775671,0.0002640218,0.0003390827,0.0001228268,0.0001025297,0.0002364875,0.00005804496],"category_scores_gemma":[0.0002960626,0.0002394937,0.0003175222,0.000529054,0.00004631554,0.0001482338,0.00003652208,0.0002162934,0.00005290877],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001846573,"about_ca_system_score_gemma":0.0001863979,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001691011,"about_ca_topic_score_gemma":0.00006266089,"domain_scores_codex":[0.9984852,0.00005105278,0.0004817968,0.0004290597,0.0001631665,0.0003897249],"domain_scores_gemma":[0.9989263,0.0001149202,0.000129747,0.000482491,0.0002412563,0.0001052465],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001156975,0.0004318914,0.04751762,0.001046882,0.0007866364,0.000008745458,0.0006683781,0.0001196251,0.9084895,0.004141607,0.03494904,0.001724331],"study_design_scores_gemma":[0.002513006,0.0003040302,0.003846508,0.0005941368,0.000603541,0.00008211065,0.0004521822,0.0002501166,0.04493025,0.00009801381,0.9459889,0.0003372435],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9099013,0.002329877,0.04149836,0.0009229531,0.006657472,0.004224455,0.0002489085,0.0007247138,0.03349203],"genre_scores_gemma":[0.9880105,0.0001214821,0.001120677,0.0005852467,0.0006432061,0.0005361781,0.00008736934,0.00004968327,0.00884561],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9110398,"threshold_uncertainty_score":0.9766268,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009444236570360542,"score_gpt":0.2723496047790508,"score_spread":0.2629053682086903,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}