{"id":"W4416998016","doi":"10.1016/j.stem.2025.10.010","title":"When the heart calls for help: Clusterin reprograms immunity to enable regeneration","year":2025,"lang":"en","type":"article","venue":"Cell stem cell","topic":"Clusterin in disease pathology","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine","funders":"National Science and Technology Council","keywords":"Clusterin; Inflammation; Regeneration (biology); Macrophage; Cognitive reframing; Mammalian heart; Efferocytosis; Immunity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006708346,0.0004512125,0.0004771629,0.0005356978,0.001235251,0.002142051,0.0005591649,0.001716606,0.007303725],"category_scores_gemma":[0.001164719,0.000304078,0.0003676067,0.0002245651,0.001548378,0.001299451,0.001608123,0.004621615,0.001917307],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001032732,"about_ca_system_score_gemma":0.0009528946,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008604521,"about_ca_topic_score_gemma":0.001748859,"domain_scores_codex":[0.9992672,0.00009966249,0.00002169322,0.0001541349,0.0001863706,0.0002709666],"domain_scores_gemma":[0.9993393,0.00006749167,0.00008751549,0.00007009884,0.00009742875,0.0003380416],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009231573,0.000083987,0.003158303,0.0003389845,0.00006840746,0.00120498,0.000884914,0.0004721375,0.8790875,0.03160022,0.04059178,0.04158561],"study_design_scores_gemma":[0.0003291079,0.0008366961,0.03437333,0.0005222844,0.0001754115,0.00389459,0.004550133,0.003689288,0.5269074,0.02923483,0.3952642,0.0002227106],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7216176,0.0502795,0.0467697,0.07254066,0.02261545,0.0002034877,0.001503359,0.003329562,0.08114062],"genre_scores_gemma":[0.9526345,0.004214451,0.006190438,0.005968994,0.001076,0.00006297441,0.0002874905,0.0004864024,0.02907864],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007303725,"threshold_uncertainty_score":0.02443337,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02499378719863435,"score_gpt":0.2900561298897898,"score_spread":0.2650623426911554,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}