{"id":"W4417001677","doi":"10.1182/blood-2025-80","title":"Efficacy and safety results from the primary analysis of the pivotal summit trial: Bezuclastinib in adults with non-advanced systemic mastocytosis","year":2025,"lang":"en","type":"article","venue":"Blood","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; University of Calgary; University of Alberta","funders":"","keywords":"Systemic mastocytosis; Clinical endpoint; Placebo; Randomized controlled trial; Summit; Quality of life (healthcare); Bone marrow; Roche Diagnostics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003966435,0.001617356,0.002225168,0.0003076413,0.0006014569,0.00150577,0.0009019683,0.001269327,0.005294022],"category_scores_gemma":[0.003003232,0.000407172,0.002352285,0.0004012562,0.0006272933,0.0009393069,0.0005896532,0.002278161,0.001034744],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0012642,"about_ca_system_score_gemma":0.001045738,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001131625,"about_ca_topic_score_gemma":0.003041602,"domain_scores_codex":[0.9987405,0.0006462949,0.00008099261,0.0002244531,0.0001529733,0.0001547933],"domain_scores_gemma":[0.9979929,0.0004022802,0.0006630535,0.0001262941,0.000349295,0.0004662642],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.921771,0.004819538,0.009300961,0.00232471,0.005185869,0.0001776758,0.000150869,0.001379508,0.005901511,0.0002739765,0.01645622,0.03225819],"study_design_scores_gemma":[0.7754404,0.1387231,0.06373875,0.0003304576,0.007585833,0.0005208858,0.000137787,0.002032781,0.0021377,0.000507255,0.008733747,0.0001112707],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9486124,0.01707849,0.0008079599,0.002439925,0.000461314,0.003015159,0.01832389,0.0001867012,0.009074153],"genre_scores_gemma":[0.9746761,0.002928751,0.0006993727,0.001478416,0.0005035636,0.00221923,0.01517737,0.0000373357,0.002279843],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005294022,"threshold_uncertainty_score":0.02097678,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004579965691352419,"score_gpt":0.1965166068008762,"score_spread":0.1919366411095237,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}