{"id":"W4417001848","doi":"10.1182/blood-2025-325","title":"Lipid uptake via FATP2 enhances CAR-t therapy resistance in B-cell acute lymphoblastic leukemia","year":2025,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Leukemia; Chemotherapy regimen; Acute lymphocytic leukemia; Chemotherapy; Antigen; T-cell leukemia; Perforin; T cell; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001497449,0.0003117993,0.0003562233,0.0001890987,0.0001318484,0.0005647792,0.0002005539,0.0003376675,0.002819994],"category_scores_gemma":[0.0001483059,0.0001628548,0.0002790286,0.0002016043,0.0002109506,0.0003033876,0.0003036576,0.0009474395,0.001278066],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003949764,"about_ca_system_score_gemma":0.0001875145,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006832894,"about_ca_topic_score_gemma":0.0005844223,"domain_scores_codex":[0.9998621,0.00003363598,0.000005029901,0.00001593112,0.00003704471,0.00004625336],"domain_scores_gemma":[0.9999504,0.00000960721,0.000008892278,0.000008046706,0.000006931339,0.00001607131],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001089253,0.0004261743,0.0005154003,0.0001060609,0.0000211134,0.0001827883,0.00005261145,0.000501192,0.9894714,0.0003252437,0.0007208349,0.006587837],"study_design_scores_gemma":[0.0002945248,0.004770747,0.004989587,0.00001667108,0.00007799495,0.0006626609,0.0001267089,0.006459282,0.9703594,0.0002689293,0.01195987,0.00001357195],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946842,0.001571578,0.001336396,0.0002080777,0.00003840213,0.00003323881,0.0002139323,0.00017601,0.001738143],"genre_scores_gemma":[0.9966459,0.000757126,0.0004474727,0.00007865333,0.00000845366,0.00003365307,0.0003442358,0.00002823581,0.001656252],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002819994,"threshold_uncertainty_score":0.009433806,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01297697708727439,"score_gpt":0.2821483265426414,"score_spread":0.269171349455367,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}