{"id":"W4417001904","doi":"10.1002/cmdc.70134","title":"Front Cover: Lewis Acid‐Initiated Cleavage of a Large Ionophore: Molecular Deactivation by Potassium Ion Binding (ChemMedChem 23/2025)","year":2025,"lang":"en","type":"article","venue":"ChemMedChem","topic":"Molecular Sensors and Ion Detection","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Brock University","funders":"","keywords":"Divalent; Ionophore; Ion; Potassium; Molecule; Cleavage (geology); Divalent metal","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003031199,0.000465,0.0005726515,0.0002139255,0.0001784877,0.00006676211,0.0003566641,0.0005985227,0.0008565476],"category_scores_gemma":[0.0003597781,0.0005123946,0.0003079053,0.0005803555,0.00009606191,0.0001933581,0.0001776038,0.0005586227,0.0001462737],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003981216,"about_ca_system_score_gemma":0.0001277677,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004488031,"about_ca_topic_score_gemma":0.0000027325,"domain_scores_codex":[0.9972858,0.00005270855,0.0007643601,0.0007446568,0.0005264964,0.0006260119],"domain_scores_gemma":[0.998358,0.00008522479,0.0004557425,0.0007232708,0.0002064004,0.0001713897],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001516377,0.0003123645,0.0002552974,0.0003254031,0.0001796189,0.00001640685,0.0001248264,0.000005542408,0.9648973,0.00016074,0.03189036,0.001680529],"study_design_scores_gemma":[0.001799186,0.00003506946,0.00005484304,0.000231581,0.0001174248,0.000006759049,0.0002942468,0.0007644938,0.978454,0.0001631287,0.01764555,0.0004337249],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9424236,0.0008912359,0.005526956,0.0004094615,0.0003060499,0.0002316581,0.0001379444,0.0002267149,0.04984641],"genre_scores_gemma":[0.9933699,0.0001049153,0.0002964728,0.0003673779,0.00008666563,0.00006692678,0.000839484,0.00007314655,0.004795162],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05094628,"threshold_uncertainty_score":0.9997328,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01075437178522343,"score_gpt":0.2462218365039372,"score_spread":0.2354674647187137,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}