{"id":"W4417001966","doi":"10.1182/blood-2025-2738","title":"The influence of age on patient-reported outcomes (PROs) endpoints on the S1826 cross-network Phase III trial of advanced-stage, classic Hodgkin lymphoma (cHL)","year":2025,"lang":"en","type":"article","venue":"Blood","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; McGill University","funders":"","keywords":"Brentuximab vedotin; Randomization; Dacarbazine; Quality of life (healthcare); Clinical endpoint; Surrogate endpoint; Hodgkin lymphoma; Chemotherapy regimen; Phases of clinical research; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01030776,0.0006780638,0.0006533705,0.0002394514,0.0001871285,0.0005453211,0.0003756004,0.0005383526,0.00271798],"category_scores_gemma":[0.006091167,0.0002009122,0.001376268,0.0002490746,0.0003572016,0.0005838296,0.0003941517,0.001052396,0.0002751618],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002517493,"about_ca_system_score_gemma":0.0003500132,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002222381,"about_ca_topic_score_gemma":0.0005856747,"domain_scores_codex":[0.9948912,0.004234006,0.000184032,0.0002741855,0.000256235,0.0001603802],"domain_scores_gemma":[0.9942582,0.003449743,0.001442408,0.0002680761,0.0002143049,0.0003672611],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.8793149,0.003233824,0.07667977,0.0005558236,0.003612552,0.000050408,0.0001117018,0.002678727,0.003502277,0.0001872813,0.00142595,0.02864669],"study_design_scores_gemma":[0.1451898,0.3353126,0.4933406,0.0002336444,0.006084551,0.0002130656,0.0001142877,0.009918119,0.003898661,0.0006120608,0.005010249,0.00007232084],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994998,0.001861374,0.0004114522,0.0001558707,0.00005769016,0.0002578582,0.0008953204,0.00001482885,0.001347651],"genre_scores_gemma":[0.9972622,0.0002622106,0.0003845202,0.0001260709,0.00006472113,0.000500385,0.0007521593,0.00000868239,0.00063914],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01030776,"threshold_uncertainty_score":0.05451328,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01630886923820037,"score_gpt":0.3165869747371246,"score_spread":0.3002781054989243,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}