{"id":"W4417002049","doi":"10.1182/blood-2025-1101","title":"Comparative efficacy of complement inhibitors in complement Inhibitor–Naïve PNH: A network meta-analysis of randomized trials","year":2025,"lang":"en","type":"article","venue":"Blood","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of New Brunswick","funders":"","keywords":"Paroxysmal nocturnal hemoglobinuria; Randomized controlled trial; Eculizumab; Complement (music); Clinical trial; Randomization; Complement component 5","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03465002,0.003349729,0.01837053,0.006508699,0.00056384,0.003528218,0.002775377,0.002223951,0.004731916],"category_scores_gemma":[0.06828657,0.001494185,0.05550454,0.006396501,0.0007937205,0.002198816,0.0019761,0.002564232,0.0003562073],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002214927,"about_ca_system_score_gemma":0.00246102,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004242058,"about_ca_topic_score_gemma":0.005835339,"domain_scores_codex":[0.9631428,0.02664275,0.005031885,0.002685364,0.00188554,0.0006116957],"domain_scores_gemma":[0.9456074,0.04585107,0.004534508,0.001986043,0.001602175,0.0004188644],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.003143912,0.000017612,0.003244939,0.07152577,0.9174896,0.00005579718,0.00003252604,0.0008158589,0.000101299,0.0001596956,0.0003093099,0.003103546],"study_design_scores_gemma":[0.001056779,0.0001490101,0.00183107,0.003938967,0.9913459,0.00003018098,0.00001997118,0.0005709435,0.00006807529,0.000356082,0.0006179306,0.00001501121],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.02432339,0.9614632,0.007030589,0.0008617615,0.0007222652,0.001723045,0.002839039,0.0001552585,0.0008814937],"genre_scores_gemma":[0.7032432,0.2674564,0.01504856,0.001856027,0.0006273397,0.006726176,0.003891585,0.0001768649,0.0009738394],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.03465002,"threshold_uncertainty_score":0.1832491,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1363188031666678,"score_gpt":0.3771899923326464,"score_spread":0.2408711891659786,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}