{"id":"W4417002052","doi":"10.1182/blood-2025-1845","title":"External validation of the early-stage classic Hodgkin lymphoma (cHL) international prognostication index (E-HIPI) in the german Hodgkin study group (GHSG) unfavorable clinical trials","year":2025,"lang":"en","type":"article","venue":"Blood","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; BC Cancer Agency; Canadian Cancer Society; University of Toronto","funders":"","keywords":"ABVD; Clinical trial; Hodgkin lymphoma; Brentuximab vedotin; International Prognostic Index; Lymphoma; Cohort; Chemotherapy regimen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.09790416,0.0009946997,0.00127503,0.0007130526,0.000573075,0.002450838,0.001528304,0.001191532,0.003785981],"category_scores_gemma":[0.1036919,0.0004139178,0.001682262,0.001227796,0.001153652,0.001373373,0.002715839,0.001659337,0.001603258],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001047945,"about_ca_system_score_gemma":0.002231271,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007188705,"about_ca_topic_score_gemma":0.001157778,"domain_scores_codex":[0.9615735,0.03021924,0.00280278,0.002569248,0.002240763,0.0005944141],"domain_scores_gemma":[0.9331563,0.0305347,0.01343256,0.01233318,0.007747901,0.002795426],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1677533,0.002169115,0.5912962,0.003893001,0.01495008,0.0002320179,0.0008753925,0.0114493,0.00262252,0.004085184,0.04973646,0.1509375],"study_design_scores_gemma":[0.07764135,0.03059077,0.7188193,0.003661868,0.01530643,0.001004328,0.0004216789,0.03198131,0.006722758,0.01015541,0.1033714,0.000323499],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8895234,0.0104996,0.02135215,0.003543064,0.001145936,0.01331951,0.03743106,0.0006006209,0.02258463],"genre_scores_gemma":[0.9367275,0.0008433119,0.01059084,0.001739943,0.0003196893,0.01054302,0.03758685,0.0001851731,0.001463753],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09790416,"threshold_uncertainty_score":0.5177729,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06479326219693014,"score_gpt":0.4040638090016049,"score_spread":0.3392705468046747,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}