{"id":"W4417002254","doi":"10.1158/1538-7445.canevol25-b004","title":"Abstract B004: Mapping loss of heterozygosity in Li-Fraumeni syndrome to uncover early molecular drivers of tumorigenesis","year":2025,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Loss of heterozygosity; Carcinogenesis; Allele; Germline; Cancer; Germline mutation; Somatic cell; Tumor suppressor gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001535344,0.0002487862,0.0002170325,0.0008400953,0.0002426563,0.000336791,0.0002144473,0.0003459575,0.002955235],"category_scores_gemma":[0.0002863619,0.0001366164,0.0002791803,0.0003637601,0.0001751951,0.0001093237,0.0002091749,0.0004807947,0.001155796],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001997259,"about_ca_system_score_gemma":0.0001774263,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001364734,"about_ca_topic_score_gemma":0.00225687,"domain_scores_codex":[0.999864,0.00001348208,0.00001533256,0.00004198444,0.00003906146,0.00002607743],"domain_scores_gemma":[0.9998422,0.00005182078,0.00003503418,0.00002361884,0.00002154804,0.00002575424],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004248998,0.00001612035,0.002670416,0.00002465911,0.000004008909,0.0004818935,0.00002897374,0.00005599501,0.9930861,0.00006418629,0.0001254746,0.003399682],"study_design_scores_gemma":[0.00001235896,0.0003260896,0.07744998,0.00002305022,0.00003854157,0.007126795,0.0001451332,0.001568177,0.9021689,0.0001646013,0.01095876,0.00001758222],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9712289,0.002024414,0.01798354,0.0002169289,0.00007305813,0.0001473826,0.005130764,0.0002639932,0.002930989],"genre_scores_gemma":[0.971306,0.001155522,0.01861795,0.0001525718,0.00002046536,0.0001010331,0.004540935,0.00009018889,0.00401532],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002955235,"threshold_uncertainty_score":0.009886205,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03780029639250727,"score_gpt":0.3689225692814465,"score_spread":0.3311222728889393,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}