{"id":"W4417004501","doi":"10.1182/blood-2025-1114","title":"Switching between complement inhibitors in patients with PNH: A real-world analysis of strategy, efficacy, and safety.","year":2025,"lang":"en","type":"article","venue":"Blood","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Associated Medical Services","funders":"","keywords":"Paroxysmal nocturnal hemoglobinuria; Hemolysis; Eculizumab; Thrombosis; Clinical trial; Cohort; Off-label use","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003485134,0.0002941012,0.0005895616,0.0008446661,0.0004055411,0.001121515,0.0003496727,0.0004885475,0.00277548],"category_scores_gemma":[0.0061051,0.0001933811,0.001171576,0.001494986,0.0004459371,0.0009494785,0.0007269467,0.0007433493,0.0003701462],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00118699,"about_ca_system_score_gemma":0.000560772,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009422578,"about_ca_topic_score_gemma":0.0008977503,"domain_scores_codex":[0.9975482,0.001034489,0.0003359101,0.0004626316,0.0004192524,0.0001995179],"domain_scores_gemma":[0.9923653,0.002209983,0.003947691,0.0003535319,0.0005117437,0.0006116966],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0205641,0.0008149821,0.9405847,0.0004234595,0.001689456,0.0001922553,0.0002666976,0.0007251414,0.000475933,0.0002444586,0.001412558,0.03260622],"study_design_scores_gemma":[0.001395214,0.01347942,0.9741189,0.0002423142,0.001175416,0.0009896395,0.0006693561,0.002829636,0.0006125825,0.0005024614,0.003910684,0.00007435738],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935736,0.002452315,0.000491759,0.0001485135,0.00002028912,0.0001870523,0.002019185,0.00001188178,0.001095409],"genre_scores_gemma":[0.9978178,0.0002656172,0.00030593,0.00008995688,0.00002108856,0.00009127639,0.001257064,0.000002730097,0.0001485415],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003485134,"threshold_uncertainty_score":0.01843137,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01105636493721518,"score_gpt":0.2628794024825541,"score_spread":0.2518230375453389,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}