{"id":"W4417004914","doi":"10.1182/blood-2025-1048","title":"Lipid nanoparticle-mediated epitope editing in human HSPCs enables resistance to CD45-directed CAR-T cell therapy","year":2025,"lang":"en","type":"article","venue":"Blood","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"WSP (Canada)","funders":"","keywords":"Epitope; Electroporation; Haematopoiesis; Ex vivo; Stem cell; Genome editing; Progenitor cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001583915,0.0001574125,0.0001835013,0.00008024456,0.00008125637,0.0002606468,0.0000839604,0.0002425215,0.0007192146],"category_scores_gemma":[0.0001529359,0.00007214212,0.0001413789,0.00007192382,0.0001284,0.0001149942,0.0001295622,0.0003043457,0.0002483747],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001782903,"about_ca_system_score_gemma":0.0001042462,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005560645,"about_ca_topic_score_gemma":0.0004998051,"domain_scores_codex":[0.9998666,0.00001929959,0.00001038824,0.0000349557,0.00004031166,0.00002850989],"domain_scores_gemma":[0.9999391,0.00001693848,0.00001395405,0.000009404864,0.00001266461,0.000008027959],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004318196,0.0000146227,0.00007308864,0.00001419203,0.000002616628,0.00002422208,0.00001408357,0.0001541057,0.9985899,0.00005285812,0.00002838088,0.000988635],"study_design_scores_gemma":[0.000003647532,0.0001169623,0.0003885578,0.00000138231,0.000005468642,0.0000640713,0.000006911905,0.000762144,0.9977859,0.000009176945,0.0008538356,0.000001856932],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928012,0.0003666838,0.005727422,0.0000341558,0.00001752147,0.00003722784,0.0001157372,0.00007117716,0.0008289358],"genre_scores_gemma":[0.9968802,0.0001662363,0.001652862,0.00001518052,0.000001841405,0.00001691222,0.0001107476,0.00001221987,0.001143767],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007192146,"threshold_uncertainty_score":0.002406001,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004866321082779813,"score_gpt":0.2568045748622024,"score_spread":0.2519382537794226,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}