{"id":"W4417004958","doi":"10.1182/blood-2025-1030","title":"Antigen-dependent clonal sweep with sequential or combinatory anti-myeloma T cell engagers","year":2025,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research","funders":"","keywords":"Antigen; Mutation; Bone marrow; Flow cytometry; T cell; Chimeric antigen receptor; Multiple myeloma; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001983842,0.0002195323,0.0003392702,0.0002123783,0.0001351469,0.0004093945,0.0002583133,0.0002255636,0.001957666],"category_scores_gemma":[0.0002301431,0.0001210207,0.0001952535,0.0002010003,0.0001581306,0.0001943854,0.0004150386,0.0005578639,0.0003944859],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001834512,"about_ca_system_score_gemma":0.0001647717,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002587551,"about_ca_topic_score_gemma":0.0008565048,"domain_scores_codex":[0.9997714,0.0000233193,0.00001456,0.00006498219,0.00005592063,0.0000698772],"domain_scores_gemma":[0.9998769,0.00002757652,0.00002478217,0.00002648389,0.00001630477,0.00002793066],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004036521,0.0001703512,0.002645245,0.00009643615,0.00002957258,0.0001343004,0.00005544521,0.0008676805,0.9715621,0.0002950828,0.0004642211,0.02327598],"study_design_scores_gemma":[0.0001206563,0.003657825,0.01507628,0.00002297138,0.0001244184,0.001287188,0.00009321393,0.01051772,0.9556033,0.0004001016,0.01307916,0.00001719053],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925599,0.0009535254,0.003774247,0.00008200508,0.00003349999,0.00008306603,0.0003013551,0.0002138038,0.001998634],"genre_scores_gemma":[0.995615,0.000291575,0.002189533,0.00009338639,0.00001857121,0.00006745976,0.000268622,0.00002318611,0.001432749],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001957666,"threshold_uncertainty_score":0.006549001,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01974154557983326,"score_gpt":0.2906007486731664,"score_spread":0.2708592030933332,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}