{"id":"W4417005998","doi":"10.1182/blood-2025-3199","title":"Maternal and fetal pharmacokinetics (PK) of pegcetacoplan in paroxysmal nocturnal hemoglobinuria (PNH): A case report of use in pregnancy","year":2025,"lang":"en","type":"article","venue":"Blood","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; London Health Sciences Centre; Western University","funders":"","keywords":"Eculizumab; Pregnancy; Paroxysmal nocturnal hemoglobinuria; Anemia; Gestation; Hemolytic anemia; Gestational age; Hematologic disease; Erythropoietin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001357247,0.0001271533,0.0003303913,0.0001938323,0.00001961197,0.000006861227,0.0001062793,0.00008128447,0.0001138571],"category_scores_gemma":[0.00006286534,0.000122053,0.00004846595,0.0001363801,0.0001000741,0.00005506403,0.0001179527,0.000121998,0.000001669981],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001494064,"about_ca_system_score_gemma":0.00007386291,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008008154,"about_ca_topic_score_gemma":0.0005607613,"domain_scores_codex":[0.9987726,0.0001378806,0.0006493737,0.00021098,0.00003345812,0.0001957692],"domain_scores_gemma":[0.9994323,0.00009124407,0.0002118345,0.0002088278,0.00004012549,0.00001563549],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001650086,0.0005028248,0.9180418,0.0002783092,0.0001554198,0.008359188,0.0001288074,0.000006801168,0.0718968,0.00006663919,0.0001171057,0.0002813551],"study_design_scores_gemma":[0.01168179,0.0001429137,0.6510372,0.001279747,0.0002672219,0.02465374,0.0001466686,0.00001145576,0.3103085,0.00007972225,0.000209079,0.0001819337],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954461,0.003615309,0.000007116528,0.00001817471,0.0002276368,0.000327601,0.0001296112,0.00001008591,0.0002183752],"genre_scores_gemma":[0.999492,0.00003152749,0.00009379444,0.000008405532,0.000006827957,0.00001916079,0.00002177614,0.000006243059,0.000320253],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2670045,"threshold_uncertainty_score":0.4977177,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01520342154950765,"score_gpt":0.2712587877385272,"score_spread":0.2560553661890196,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}