{"id":"W4417006141","doi":"10.1182/blood-2025-3293","title":"LSD1 inhibition enhances venetoclax efficacy in Acute Myeloid Leukemia via metabolic rewiring","year":2025,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Juravinski Cancer Centre; Population Health Research Institute; McMaster University; Hamilton Health Sciences","funders":"","keywords":"Venetoclax; Myeloid leukemia; Azacitidine; Clofarabine; NPM1; Leukemia; In vivo; Myeloid; Cytarabine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009975265,0.0002019742,0.0001817259,0.000169356,0.00009947539,0.0001579723,0.0001290758,0.0001140901,0.00199873],"category_scores_gemma":[0.00008024273,0.00006051321,0.0001550675,0.0001197078,0.000135403,0.00009315269,0.0001154729,0.0004182754,0.000259011],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001756394,"about_ca_system_score_gemma":0.0001310402,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004225993,"about_ca_topic_score_gemma":0.0008781027,"domain_scores_codex":[0.9999475,0.0000106975,0.000005305459,0.00001127879,0.00001217239,0.00001300532],"domain_scores_gemma":[0.9999548,0.000009593729,0.00001150353,0.000005770575,0.000004839143,0.00001335769],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007495582,0.0001395926,0.0003805745,0.00007872879,0.00001042288,0.00002274078,0.00001454845,0.0001968444,0.9926811,0.00005515719,0.0001859536,0.005484798],"study_design_scores_gemma":[0.00007171124,0.002366506,0.006118971,0.000007588014,0.00002198741,0.0001699244,0.0000180617,0.0007022835,0.98782,0.00002623355,0.002671428,0.000005285535],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964886,0.001266556,0.0005031061,0.0000460286,0.00002068234,0.00002876753,0.000428148,0.00009325296,0.001124967],"genre_scores_gemma":[0.9969378,0.0005107957,0.0007664951,0.00002075512,0.000006244208,0.00001951999,0.0005030778,0.000006919134,0.001228346],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00199873,"threshold_uncertainty_score":0.006686389,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01175402913000026,"score_gpt":0.2939082699760667,"score_spread":0.2821542408460664,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}