{"id":"W4417006291","doi":"10.1182/blood-2025-2590","title":"Cost-effectiveness of hydroxyurea for children with sickle cell disease in sub-saharan Africa: A discrete event simulation model to inform policy and government planning","year":2025,"lang":"en","type":"article","venue":"Blood","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Providence Health Care","funders":"","keywords":"Disease; Government (linguistics); Population; Clinical trial; Disease burden; Developed country; Public health; Cost effectiveness","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002602919,0.001402845,0.001786745,0.001382111,0.0006943266,0.001906976,0.001755311,0.003277459,0.01058806],"category_scores_gemma":[0.01119558,0.0007247698,0.001772082,0.001161238,0.0008412689,0.001304307,0.001443231,0.002692818,0.0004064754],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003830363,"about_ca_system_score_gemma":0.003837108,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.08413867,"about_ca_topic_score_gemma":0.02613765,"domain_scores_codex":[0.9990884,0.0005274325,0.00002728856,0.00008584093,0.00004758269,0.0002234445],"domain_scores_gemma":[0.988853,0.009398035,0.0005382602,0.00008758979,0.0005625972,0.0005604645],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0002616183,0.00009989493,0.003632361,0.0000518512,0.00005852097,0.0001403395,0.00002815853,0.9897465,0.00004392111,0.003566577,0.001003076,0.001367213],"study_design_scores_gemma":[0.0001673841,0.0001003396,0.0008269671,0.00002902612,0.00005300297,0.00002163769,0.000109071,0.996237,0.0000292718,0.001969204,0.0004443082,0.00001281567],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8982269,0.003158797,0.05264855,0.01026933,0.0004306315,0.0006137507,0.00786416,0.0003218903,0.02646597],"genre_scores_gemma":[0.987448,0.0006509125,0.006204775,0.0003075488,0.0000497559,0.0002846252,0.00108024,0.00002680387,0.003947295],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08413867,"threshold_uncertainty_score":0.1672978,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01299192010957373,"score_gpt":0.2848333626393113,"score_spread":0.2718414425297376,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}