{"id":"W4417006596","doi":"10.1182/blood-2025-5717","title":"P300/CBP acetyltransferase inhibition and degradation disrupt oncogenic transcriptional programs and reveal epigenetic vulnerabilities in multiple myeloma","year":2025,"lang":"en","type":"article","venue":"Blood","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"","keywords":"Epigenetics; Bromodomain; Acetylation; Transcriptional regulation; Histone; Chromatin; Demethylase; BRD4; Histone acetyltransferase; P300-CBP Transcription Factors","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002062071,0.0003118579,0.0004589085,0.000330398,0.0001908303,0.0003549219,0.0002386432,0.0002448834,0.001398242],"category_scores_gemma":[0.0001067988,0.0001481169,0.0003476658,0.0003848339,0.0001885461,0.0001446629,0.0001792562,0.0006832608,0.0003837704],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004377196,"about_ca_system_score_gemma":0.0002333211,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008678545,"about_ca_topic_score_gemma":0.001522629,"domain_scores_codex":[0.9998401,0.00001057127,0.00001038719,0.00003932449,0.00006797695,0.00003165059],"domain_scores_gemma":[0.9999483,0.000009136914,0.00001449033,0.00001003882,0.000009567088,0.000008478469],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002100383,0.00004976933,0.001043336,0.00007459115,0.00003078306,0.00003794974,0.00001194728,0.000471236,0.992799,0.00006916715,0.000217929,0.004984214],"study_design_scores_gemma":[0.00003206143,0.0005384542,0.02108565,0.000008640003,0.00007465034,0.000240188,0.00004684602,0.003515406,0.9708306,0.0001309027,0.003487854,0.000008833666],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9853309,0.00337872,0.004723122,0.00016575,0.00002836849,0.00006373615,0.004248686,0.0003870694,0.001673598],"genre_scores_gemma":[0.9904813,0.001631778,0.002681488,0.0001081424,0.000007146783,0.00007710021,0.002871556,0.0000335473,0.002107831],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001398242,"threshold_uncertainty_score":0.004677594,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01019295828391266,"score_gpt":0.2298670312232886,"score_spread":0.2196740729393759,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}