{"id":"W4417006971","doi":"10.1182/blood-2025-682","title":"Long-term immune reconstitution and final 1-year follow-up after fixed-duration venetoclax-obinutuzumab (VenO) in first-line (1L) chronic lymphocytic leukemia (CLL): Results from the Phase III CRISTALLO trial","year":2025,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Hospital Foundation","funders":"","keywords":"Immune system; Chronic lymphocytic leukemia; Clinical endpoint; Antibody; Lymphocyte; Minimal residual disease; Surrogate endpoint; Cytokine release syndrome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002064452,0.0004531101,0.000847796,0.0001961221,0.0003642097,0.0009505366,0.0003859386,0.0008565517,0.001201353],"category_scores_gemma":[0.001165555,0.0001949382,0.0009016928,0.00026964,0.0003379799,0.0004919415,0.0003076102,0.001212473,0.0002662285],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004307094,"about_ca_system_score_gemma":0.0003074486,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006494119,"about_ca_topic_score_gemma":0.001051896,"domain_scores_codex":[0.9995199,0.0002235597,0.00002799929,0.00008772644,0.00005155209,0.00008913428],"domain_scores_gemma":[0.9989773,0.0002264083,0.0003016396,0.0001141218,0.00006190663,0.0003185862],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7599182,0.007571316,0.1320947,0.0004117411,0.002755708,0.0002414628,0.0003371952,0.0017374,0.009058543,0.0001466614,0.002245779,0.08348134],"study_design_scores_gemma":[0.1152609,0.3288749,0.5362148,0.0001893841,0.004718863,0.001017722,0.0002200626,0.002465763,0.00503718,0.0004470359,0.005454287,0.00009912824],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965757,0.002120513,0.00008927351,0.00006617094,0.00002404424,0.00009165696,0.0004380426,0.000009041025,0.0005855238],"genre_scores_gemma":[0.9974557,0.0005115634,0.0001139662,0.0001218513,0.00004755611,0.000120276,0.001136389,0.000003547639,0.0004892604],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002064452,"threshold_uncertainty_score":0.01091802,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02385653646273094,"score_gpt":0.3018834794210207,"score_spread":0.2780269429582898,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}