{"id":"W4417007123","doi":"10.1182/blood-2025-2024","title":"Avapritinib achieves deep and durable symptom control with a well-tolerated safety profile in ism: Long-term outcomes from pioneer","year":2025,"lang":"en","type":"article","venue":"Blood","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; University of Calgary","funders":"","keywords":"Systemic mastocytosis; Disease; Distress; Adverse effect; Neutropenia; Maintenance therapy; Clinical trial; Mast cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001248504,0.0003639317,0.00109407,0.0001868125,0.0002462042,0.0007918333,0.0003363255,0.000544296,0.003044698],"category_scores_gemma":[0.0009986236,0.0001134854,0.001102527,0.0002283386,0.000309882,0.0006791396,0.0002739219,0.001904264,0.0008317276],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004579507,"about_ca_system_score_gemma":0.0007780092,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005977924,"about_ca_topic_score_gemma":0.001907113,"domain_scores_codex":[0.9996769,0.00007435431,0.0000227238,0.00007170025,0.00007797305,0.00007629336],"domain_scores_gemma":[0.9993267,0.0001043887,0.0001746227,0.00007569991,0.00009502097,0.0002235297],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.1767129,0.02108227,0.02622264,0.002738447,0.003124337,0.0008091989,0.0004185489,0.004238155,0.08449659,0.0008279901,0.04156998,0.6377588],"study_design_scores_gemma":[0.1489703,0.5373396,0.2196401,0.0004673268,0.003564399,0.00627875,0.0003289899,0.00515219,0.02799927,0.001512529,0.04856161,0.0001850505],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9731382,0.0141347,0.001345978,0.0009515908,0.0002174942,0.0005077412,0.003045758,0.0003581491,0.006300518],"genre_scores_gemma":[0.9887111,0.003013143,0.0007867456,0.0007791839,0.0001809568,0.0002092297,0.004344839,0.00003815122,0.001936863],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003044698,"threshold_uncertainty_score":0.01018554,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00450742105113864,"score_gpt":0.2000907534720145,"score_spread":0.1955833324208758,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}