{"id":"W4417008411","doi":"10.1182/blood-2025-204","title":"Anti-PF4 antibodies are a potential mediator of antisense oligonucleotide (ASO)-induced thrombocytopenia.","year":2025,"lang":"en","type":"article","venue":"Blood","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Lethbridge","funders":"","keywords":"Oligonucleotide; RNase P; Antibody; RNA; Mediator; Nucleic acid; RNase H; Mechanism of action; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002874917,0.0003798854,0.0001682161,0.0003007399,0.0001204777,0.0001914121,0.0002417951,0.0004731065,0.002091635],"category_scores_gemma":[0.0002236301,0.0001332316,0.0002082809,0.0001298294,0.0001656041,0.0001954698,0.0001410849,0.0002778383,0.000328095],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002261826,"about_ca_system_score_gemma":0.0001658306,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001639145,"about_ca_topic_score_gemma":0.0001369948,"domain_scores_codex":[0.9998179,0.00005217786,0.00001512609,0.00003407585,0.00004175117,0.00003898014],"domain_scores_gemma":[0.9998944,0.00003411098,0.00003548611,0.000006023656,0.00001443788,0.00001554878],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006812719,0.0001711637,0.001201184,0.0001796122,0.00001596873,0.0003169768,0.00002458908,0.0001171639,0.9891717,0.0002685044,0.0001431719,0.007708813],"study_design_scores_gemma":[0.0001812637,0.006435404,0.01231445,0.00001818877,0.00006904229,0.002021889,0.00005365591,0.001117024,0.9723396,0.0001863952,0.005254367,0.000008710206],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923514,0.002463131,0.002587013,0.0001038192,0.00007057362,0.00007699813,0.0001404371,0.00006820512,0.002138317],"genre_scores_gemma":[0.9946002,0.001048545,0.001772564,0.0001037079,0.00003774133,0.0000648731,0.0002617477,0.000004057787,0.002106554],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002091635,"threshold_uncertainty_score":0.006997228,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005274219201199513,"score_gpt":0.2348420998560513,"score_spread":0.2295678806548518,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}