{"id":"W4417008902","doi":"10.1182/blood-2025-2976","title":"Hibiscus 2 (Trial-in-Progress): A global, Phase 3, randomized, double-blind, placebo-controlled study evaluating the efficacy and safety of etavopivat in adolescents and adults with sickle cell disease","year":2025,"lang":"en","type":"article","venue":"Blood","topic":"Hibiscus Plant Research Studies","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Hemolysis; Sickle cell anemia; Red blood cell; Dosing; Haemolysis; Hemolytic anemia; Anemia; Hemoglobin","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004163402,0.0003308713,0.001099319,0.0001865609,0.0002525913,0.00003909801,0.0002598031,0.0001185046,0.00001941923],"category_scores_gemma":[0.0006271655,0.0001931396,0.0000867982,0.0004944162,0.0005957459,0.00007320406,0.0002803346,0.0006321954,0.000002211867],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000407878,"about_ca_system_score_gemma":0.000248262,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007783684,"about_ca_topic_score_gemma":0.0003867904,"domain_scores_codex":[0.9952738,0.002520977,0.0007806594,0.0005327706,0.0003756704,0.000516143],"domain_scores_gemma":[0.997325,0.001861007,0.0002445327,0.0002760242,0.0001154957,0.0001779506],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8912134,0.01040284,0.09375924,0.0003288288,0.0006805555,0.0001192027,0.001311137,0.00009196263,0.00009096699,0.00004790145,0.00002400989,0.001929931],"study_design_scores_gemma":[0.9896001,0.00140579,0.004417361,0.0004105124,0.001599513,0.000002689538,0.000758621,0.001351797,0.0002161436,0.00003133256,0.00002068696,0.0001854363],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9751123,0.007129998,0.00000266939,0.0005940607,0.0001094059,0.01656045,0.00005248935,0.00002510028,0.0004134812],"genre_scores_gemma":[0.9979882,0.000563996,0.00002207202,0.00007742839,0.00004307317,0.001204011,0.000008224,0.00001120582,0.00008178221],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09838669,"threshold_uncertainty_score":0.7876005,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06632244761578317,"score_gpt":0.4549998098580316,"score_spread":0.3886773622422485,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}