{"id":"W4417008902","doi":"10.1182/blood-2025-2976","title":"Hibiscus 2 (Trial-in-Progress): A global, Phase 3, randomized, double-blind, placebo-controlled study evaluating the efficacy and safety of etavopivat in adolescents and adults with sickle cell disease","year":2025,"lang":"en","type":"article","venue":"Blood","topic":"Hibiscus Plant Research Studies","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Hemolysis; Sickle cell anemia; Red blood cell; Dosing; Haemolysis; Hemolytic anemia; Anemia; Hemoglobin","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001873862,0.001513577,0.002950438,0.0003715476,0.0004866131,0.001158305,0.0009912971,0.002022315,0.008971741],"category_scores_gemma":[0.001032114,0.000616294,0.001756473,0.000339747,0.001013846,0.00136759,0.00039416,0.003396256,0.001190338],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004365206,"about_ca_system_score_gemma":0.0009839948,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006430644,"about_ca_topic_score_gemma":0.001513982,"domain_scores_codex":[0.999562,0.0002119928,0.00002893739,0.00009645475,0.00003326956,0.0000673457],"domain_scores_gemma":[0.9994413,0.0001257824,0.0001422377,0.00004104754,0.00005635856,0.0001932098],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9451237,0.01257012,0.0006422572,0.002255416,0.001459925,0.00007962024,0.0001074114,0.0002828844,0.009216776,0.0002435627,0.002244548,0.02577369],"study_design_scores_gemma":[0.9532017,0.04317136,0.001415862,0.00005858777,0.0003205632,0.00004984039,0.00003275852,0.0002138258,0.0003833274,0.0001228524,0.001017418,0.00001195769],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.9528278,0.02144241,0.002359543,0.001812097,0.0009945759,0.01033727,0.004454197,0.0006717806,0.005100376],"genre_scores_gemma":[0.9480995,0.01123321,0.006053311,0.005084368,0.0008515221,0.01592359,0.003862561,0.0001275328,0.008764372],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.008971741,"threshold_uncertainty_score":0.0300135,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06632244761578317,"score_gpt":0.4549998098580316,"score_spread":0.3886773622422485,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}