{"id":"W4417009462","doi":"10.1182/blood-2025-3440","title":"CYP3A4 inhibitors (CYP3A4i) and myelosuppression in patients (Pts) with newly diagnosed mutant isocitrate dehydrogenase 1 (mIDH1) Acute Myeloid Leukemia (AML) in the phase 3 AGILE study","year":2025,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Neutropenia; Febrile neutropenia; Adverse effect; Concomitant; CYP3A4; Venetoclax; Placebo; Pharmacokinetics; Myeloid leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001397098,0.0003569456,0.0008351281,0.0001938259,0.0001999454,0.0007078015,0.0002687026,0.0003853056,0.002203607],"category_scores_gemma":[0.001431636,0.0002333807,0.001696553,0.0004520029,0.0001766932,0.0003654085,0.0003407245,0.001634525,0.0002245414],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003305741,"about_ca_system_score_gemma":0.0007347958,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004146703,"about_ca_topic_score_gemma":0.001429106,"domain_scores_codex":[0.9993402,0.0003781038,0.00005305268,0.00007696612,0.00008648154,0.00006513877],"domain_scores_gemma":[0.999025,0.0002359102,0.0003785268,0.00005552784,0.0000683298,0.0002366879],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.4926974,0.007468868,0.2606336,0.002952337,0.01229412,0.0004699461,0.0003559612,0.002023285,0.01533755,0.0006206067,0.01151732,0.193629],"study_design_scores_gemma":[0.2256221,0.1738958,0.5463637,0.0007269538,0.0151762,0.00158556,0.0003503298,0.002695399,0.006042107,0.001290784,0.02615464,0.00009634464],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9836321,0.01118864,0.0003448586,0.0007683064,0.0001078221,0.0005337726,0.001831255,0.00002008438,0.001573153],"genre_scores_gemma":[0.992364,0.003151345,0.000725118,0.0006896857,0.0001355322,0.0004346695,0.001777904,0.000008751256,0.0007129769],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002203607,"threshold_uncertainty_score":0.007388651,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008985298497670649,"score_gpt":0.2816159533569345,"score_spread":0.2726306548592638,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}