{"id":"W4417010092","doi":"10.1182/blood-2025-7849","title":"Inhibitors of RAD51 as potential novel therapies in Acute Myeloid Leukemia","year":2025,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; Lawson Health Research Institute; McMaster University; McMaster University Medical Centre","funders":"","keywords":"RAD51; Myeloid leukemia; Homologous recombination; Synthetic lethality; DNA repair; Cancer cell; Myeloid; Cancer; Cell culture","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001997543,0.0002931324,0.0003477149,0.0003348246,0.0001017519,0.0003308109,0.0002580613,0.0002591479,0.003423269],"category_scores_gemma":[0.00008296887,0.00006480228,0.0002267461,0.0002345671,0.0001341356,0.0001763079,0.0001935881,0.0007043502,0.0008519971],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003032641,"about_ca_system_score_gemma":0.0001708042,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002241623,"about_ca_topic_score_gemma":0.0006431138,"domain_scores_codex":[0.9999551,0.0000104292,0.000004774382,0.000006425466,0.00001019865,0.00001308811],"domain_scores_gemma":[0.9999602,0.000006830919,0.00001063451,0.000003146914,0.000006705988,0.00001259999],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003611614,0.001301033,0.001938705,0.002006106,0.0001164984,0.0007376181,0.00008216425,0.002320947,0.507147,0.005321229,0.00992399,0.4654931],"study_design_scores_gemma":[0.003557507,0.0211299,0.01830691,0.0005739314,0.0003751846,0.005047055,0.0001003162,0.003732878,0.4775172,0.002224088,0.4673817,0.00005331963],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5591704,0.3874578,0.008480963,0.002700809,0.0008802468,0.0006821502,0.001872818,0.0007378518,0.03801698],"genre_scores_gemma":[0.8782064,0.09837179,0.006251839,0.0009460877,0.0002308035,0.0002494641,0.002017149,0.00003792494,0.01368856],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003423269,"threshold_uncertainty_score":0.01145202,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009361340339531064,"score_gpt":0.2795919969100128,"score_spread":0.2702306565704817,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}