{"id":"W4417010229","doi":"10.1182/blood-2025-235","title":"Subgroup analyses from the randomized, Phase 3 VERONA study of venetoclax with azacitidine (Ven+Aza) versus placebo with azacitidine (Pbo+Aza) in patients with treatment-naïve, intermediate and higher-risk Myelodysplastic Syndromes (HR MDS)","year":2025,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital de l'Enfant-Jésus","funders":"","keywords":"Azacitidine; Clinical endpoint; Myelodysplastic syndromes; Subgroup analysis; International Prognostic Scoring System; Placebo; Neutropenia; Phases of clinical research; Surrogate endpoint; Eltrombopag","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004632798,0.001126065,0.001960314,0.0004148342,0.0002735691,0.0008127538,0.000640172,0.0009167677,0.003552293],"category_scores_gemma":[0.004450006,0.0003188204,0.006840564,0.0003698249,0.0003313753,0.0004570897,0.0005860114,0.001502834,0.000183247],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000471793,"about_ca_system_score_gemma":0.0006624843,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008169209,"about_ca_topic_score_gemma":0.003927833,"domain_scores_codex":[0.996779,0.002141912,0.0003232854,0.000371053,0.0001978512,0.0001868329],"domain_scores_gemma":[0.9985241,0.0007672954,0.0002745976,0.0002675988,0.00005938211,0.0001070063],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8713368,0.001087192,0.02690741,0.002791868,0.06097155,0.0003512277,0.0001977315,0.001426735,0.005999507,0.0004587923,0.003297705,0.02517349],"study_design_scores_gemma":[0.6303306,0.05602361,0.1680701,0.0008515558,0.1233173,0.000576231,0.0004179589,0.004679818,0.003691091,0.002464468,0.009424425,0.0001527772],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9720237,0.01717918,0.001306415,0.0005439947,0.0006379341,0.00171823,0.004578811,0.00005443662,0.001957292],"genre_scores_gemma":[0.9917863,0.001048262,0.001057089,0.0005299996,0.0001693365,0.001129979,0.003269018,0.00001520486,0.000994814],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004632798,"threshold_uncertainty_score":0.02450091,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02219161213324807,"score_gpt":0.3095902812529072,"score_spread":0.2873986691196591,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}