{"id":"W4417011270","doi":"10.1182/blood-2025-620","title":"Protac-mediated degradation of neutrophil elastase as a potential therapeutic strategy for ELANE-related neutropenia","year":2025,"lang":"en","type":"article","venue":"Blood","topic":"Blood disorders and treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Neutrophil elastase; Haematopoiesis; Myeloid; Bone marrow; Congenital Neutropenia; Neutropenia; Elastase; Progenitor cell","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001830239,0.0003250956,0.0002641565,0.0001505777,0.0000969594,0.0002809466,0.0002524273,0.000313929,0.001210292],"category_scores_gemma":[0.0000915112,0.00006749408,0.000225053,0.00009284274,0.0001578442,0.0001446586,0.0001750851,0.0005908639,0.0002389384],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002481693,"about_ca_system_score_gemma":0.0002061153,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001887238,"about_ca_topic_score_gemma":0.0003268951,"domain_scores_codex":[0.9999058,0.00001704627,0.000009464727,0.00001617869,0.00003102,0.00002047517],"domain_scores_gemma":[0.9999444,0.000005969758,0.00002330871,0.000004408659,0.000008981192,0.00001291904],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006523306,0.0002553769,0.0004002201,0.0003048226,0.00003710919,0.0003495762,0.00001714066,0.0003982224,0.9849426,0.0003628738,0.0003753687,0.01190429],"study_design_scores_gemma":[0.0001748363,0.002244289,0.001899072,0.00002983277,0.00009394691,0.001798051,0.00002311363,0.001266056,0.9799802,0.00008166033,0.01239871,0.00001010574],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9682752,0.01775181,0.009300522,0.0005453569,0.0001839111,0.0002479784,0.0004746838,0.0002072402,0.003013307],"genre_scores_gemma":[0.9858379,0.005397254,0.004997152,0.000274012,0.00002553646,0.00009724549,0.0005158159,0.00001513473,0.002840054],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001210292,"threshold_uncertainty_score":0.004048884,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00673999174391346,"score_gpt":0.2480394293661432,"score_spread":0.2412994376222297,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}