{"id":"W4417011616","doi":"10.1182/blood-2025-5807","title":"Trial in progress: A phase 1 study to evaluate the safety and preliminary efficacy of arlocabtagene autoleucel (arlo-cel), a GPRC5D-targeted chimeric antigen receptor (CAR) T cell therapy, in combination with mezigdomide (MEZI) in patients (pts) with relapsed/refractory multiple myeloma (RRMM)","year":2025,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Chimeric antigen receptor; T cell; Clinical trial; Phases of clinical research; Cytotoxicity; Hematopoietic stem cell transplantation; Antigen; Stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002480587,0.002480638,0.002294571,0.0004058341,0.0006685858,0.001666194,0.001439563,0.002243537,0.008696293],"category_scores_gemma":[0.001419682,0.0007194538,0.001470809,0.0004409075,0.001342352,0.001511996,0.0004522857,0.005322167,0.002215964],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001184436,"about_ca_system_score_gemma":0.002424182,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001143562,"about_ca_topic_score_gemma":0.002538942,"domain_scores_codex":[0.9993427,0.0003004475,0.00002384703,0.0001306158,0.00006400155,0.0001384143],"domain_scores_gemma":[0.9989172,0.0001375383,0.0002257621,0.0001043273,0.00008041878,0.0005347238],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8003838,0.08257333,0.004158088,0.001108228,0.001541023,0.0003166856,0.0003244693,0.002024191,0.04022868,0.0006561602,0.01139794,0.05528741],"study_design_scores_gemma":[0.7063373,0.2813906,0.004092977,0.00003677435,0.0003921232,0.0002739929,0.00006117061,0.0009096137,0.002215826,0.0003810411,0.003880539,0.00002791832],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9708145,0.003595658,0.001809257,0.001822773,0.0004072074,0.009019054,0.00652216,0.0004369039,0.005572446],"genre_scores_gemma":[0.9513258,0.003497222,0.005300361,0.003427527,0.0005024736,0.01382621,0.01127861,0.0001551025,0.01068665],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008696293,"threshold_uncertainty_score":0.02909195,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01647133280331626,"score_gpt":0.3027173890597998,"score_spread":0.2862460562564835,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}