{"id":"W4417011989","doi":"10.1182/blood-2025-2178","title":"Tumor intrinsic mechanisms leading to cevostamab resistance in multiple myeloma","year":2025,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Frameshift mutation; Transcriptome; Romidepsin; Multiple myeloma; Exome sequencing; Bone marrow; Exome; Mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002203188,0.0001593702,0.0002574044,0.0003337045,0.0001336374,0.0004758983,0.0001435056,0.0002167713,0.0007164635],"category_scores_gemma":[0.0002703147,0.0001125449,0.0001995466,0.0002290068,0.0001693547,0.000202179,0.0002137436,0.000324911,0.00009858743],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003402635,"about_ca_system_score_gemma":0.0001301574,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004445081,"about_ca_topic_score_gemma":0.0006789471,"domain_scores_codex":[0.9998655,0.00002408457,0.000006936021,0.00002607101,0.00004962023,0.00002784412],"domain_scores_gemma":[0.9998955,0.00002065669,0.00004754924,0.00001076822,0.00001420474,0.00001138423],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007740221,0.0001078741,0.1856968,0.0001578309,0.0001737387,0.0006665731,0.0001988767,0.001583517,0.7764884,0.000463234,0.0002580021,0.03343114],"study_design_scores_gemma":[0.00005001543,0.000907797,0.8419216,0.00003246506,0.0001229999,0.00403358,0.0002722197,0.006057168,0.141247,0.0005262762,0.004812507,0.00001645565],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972616,0.001663716,0.0005868435,0.00004129394,0.000002766166,0.00001023216,0.000133884,0.00001151654,0.0002880695],"genre_scores_gemma":[0.9989156,0.0004064658,0.0002714109,0.00003593496,0.000005222818,0.000006859217,0.0001764234,0.000002361641,0.0001797086],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007164635,"threshold_uncertainty_score":0.002468824,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02039897027117914,"score_gpt":0.2933917908460744,"score_spread":0.2729928205748952,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}