{"id":"W4417012633","doi":"10.1182/blood-2025-3730","title":"First-line consolidation with cemacabtagene ansegedleucel (cema-cel) in patients with large B-cell lymphoma (LBCL) and minimal residual disease (MRD) after response to standard therapy: The pivotal, randomized, open‑label Phase 2 ALPHA3 study","year":2025,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Lymphoma; Minimal residual disease; Refractory (planetary science); Aggressive lymphoma; Rituximab; Phases of clinical research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008695857,0.0006924057,0.001503118,0.0002706783,0.0002412319,0.0009808097,0.0006084557,0.000932879,0.003646167],"category_scores_gemma":[0.0005012543,0.0002692734,0.001175708,0.0002946255,0.0005527768,0.0009247952,0.0003167239,0.0024748,0.0009808013],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006056721,"about_ca_system_score_gemma":0.00052644,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004570302,"about_ca_topic_score_gemma":0.0008638272,"domain_scores_codex":[0.9997393,0.0001199474,0.00001202179,0.00004278448,0.00002795234,0.0000578154],"domain_scores_gemma":[0.9994143,0.0001081676,0.0001165464,0.00004785123,0.00002666237,0.000286448],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8089926,0.0258531,0.009215208,0.000678675,0.001404577,0.0001472639,0.0001298002,0.001193827,0.01211566,0.0001831097,0.003537359,0.1365488],"study_design_scores_gemma":[0.4553341,0.5106126,0.02458475,0.0001351741,0.0009267065,0.0002988353,0.00008558518,0.001510859,0.002421797,0.0002813441,0.003775111,0.00003303551],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875684,0.009503771,0.0002576993,0.0005039478,0.0001985911,0.0003860703,0.0003255668,0.00007577084,0.001180107],"genre_scores_gemma":[0.9945531,0.002063722,0.0002936504,0.0007233132,0.0001659459,0.0002582032,0.0007753198,0.00001274726,0.001153989],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003646167,"threshold_uncertainty_score":0.01219761,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01633925364020866,"score_gpt":0.3133412292391454,"score_spread":0.2970019755989367,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}