{"id":"W4417014103","doi":"10.1182/blood-2025-8","title":"Sickle cell disease is associated with early-onset clonal hematopoiesis involving DNA damage response pathway mutations","year":2025,"lang":"en","type":"article","venue":"Blood","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Leukemia; Myeloid; Disease; Myeloid leukemia; Haematopoiesis; Somatic cell; Germline mutation; Hematopoietic stem cell transplantation; Somatic evolution in cancer; Allele","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002414608,0.0001919131,0.0001426861,0.0007270423,0.0003288541,0.0003126805,0.0001467233,0.00020779,0.002149761],"category_scores_gemma":[0.0005900071,0.0001096559,0.0001050727,0.000778357,0.000290377,0.0001161801,0.0002997201,0.0001808871,0.000145966],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001077876,"about_ca_system_score_gemma":0.0001421312,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001203091,"about_ca_topic_score_gemma":0.001262918,"domain_scores_codex":[0.9998208,0.00003187085,0.00002482798,0.00006790268,0.0000273607,0.00002731611],"domain_scores_gemma":[0.9994059,0.0001089415,0.0003188633,0.0000361209,0.00005383636,0.000076474],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00009070434,0.00001209622,0.9948833,0.00001467157,0.00001981725,0.0003077594,0.000105001,0.0000408453,0.002943999,0.00003402539,0.00007963985,0.001468204],"study_design_scores_gemma":[0.000005904461,0.00009539036,0.9954908,0.00001118174,0.0000210656,0.002977681,0.0001503271,0.0001247547,0.0007941775,0.00005127133,0.0002748376,0.000002573715],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995694,0.00008507101,0.00006703089,0.000005948229,9.324991e-7,0.000002401277,0.0001363783,0.000002579503,0.0001302657],"genre_scores_gemma":[0.9996924,0.00004084368,0.0000693395,0.00000691036,0.000001776166,0.000001348404,0.0001363899,8.681244e-7,0.00005020923],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002149761,"threshold_uncertainty_score":0.007191658,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005879899633752663,"score_gpt":0.2192029409983026,"score_spread":0.21332304136455,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}