{"id":"W4417014643","doi":"10.1182/blood-2025-2451","title":"Vorinostat for GVHD prophylaxis in children, adolescents, and young adults (AYA) shows low incidence of acute GVHD and relapse with encouraging overall survival after allogeneic hematopoietic cell transplantation (HCT): A multisite, nonrandomized clinical trial","year":2025,"lang":"en","type":"article","venue":"Blood","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children’s Health Research Institute","funders":"","keywords":"Vorinostat; Clinical endpoint; Incidence (geometry); Transplantation; Cumulative incidence; Immunosuppression; Hazard ratio; Hematopoietic stem cell transplantation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001306315,0.0004485648,0.001023048,0.0002155195,0.0003273237,0.0005223916,0.0003484833,0.0005711576,0.002826728],"category_scores_gemma":[0.0006495574,0.0002079803,0.0008451818,0.0002769769,0.0004438013,0.0004199439,0.0002592391,0.001539672,0.0003692938],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002717159,"about_ca_system_score_gemma":0.000672382,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002627409,"about_ca_topic_score_gemma":0.001107314,"domain_scores_codex":[0.9995545,0.0002702912,0.00004623856,0.00004933357,0.00003924657,0.00004051951],"domain_scores_gemma":[0.9993456,0.0001301618,0.0001638049,0.00004745688,0.00004807302,0.0002648665],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7800826,0.05294696,0.01781609,0.001621936,0.003251272,0.00020368,0.0002134097,0.0006392202,0.01821679,0.0002774155,0.002035035,0.1226955],"study_design_scores_gemma":[0.4274626,0.5326446,0.03087312,0.0001527509,0.001330797,0.0003439675,0.0001038205,0.0005925911,0.002829726,0.000168176,0.003478222,0.00001951366],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924326,0.004505286,0.0002080528,0.0002595578,0.0001044746,0.001239951,0.0003638603,0.00002248164,0.0008637966],"genre_scores_gemma":[0.9945503,0.002375437,0.0006227901,0.0003610849,0.000135238,0.000925119,0.0004366668,0.000005364087,0.0005879792],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002826728,"threshold_uncertainty_score":0.009456336,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007155817751968099,"score_gpt":0.2641225151575087,"score_spread":0.2569666974055406,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}