{"id":"W4417014954","doi":"10.1182/blood-2025-7547","title":"An open-label rollover study to assess the long-term safety of ixazomib","year":2025,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Ixazomib; Adverse effect; Common Terminology Criteria for Adverse Events; Proteasome inhibitor; Clinical endpoint","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002637321,0.0007942697,0.001375209,0.0002249275,0.000451563,0.0007784513,0.0003826804,0.0008024597,0.007337563],"category_scores_gemma":[0.001842479,0.0003282784,0.001074974,0.0003186092,0.0006124189,0.0008882034,0.000326739,0.002004419,0.0009933406],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005482153,"about_ca_system_score_gemma":0.0009253527,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000321519,"about_ca_topic_score_gemma":0.0005303695,"domain_scores_codex":[0.9992757,0.0003528243,0.00004770349,0.000123492,0.0001177547,0.00008246308],"domain_scores_gemma":[0.998406,0.0003173744,0.000551477,0.000244078,0.0001622427,0.0003187704],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7929692,0.06377166,0.01403343,0.001101366,0.001786964,0.0003594028,0.0002722799,0.0009620311,0.04701569,0.0003079528,0.004751274,0.07266884],"study_design_scores_gemma":[0.1868836,0.7583334,0.03616261,0.00007736706,0.001318262,0.0004265415,0.0001060748,0.001888372,0.007801206,0.0002726543,0.006691074,0.0000389574],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893483,0.001435081,0.001658263,0.0002536023,0.0001634156,0.003418856,0.0015139,0.0001207262,0.002087743],"genre_scores_gemma":[0.9906433,0.000631478,0.001477643,0.0005042184,0.0002092451,0.002350142,0.001718662,0.0000281963,0.002437158],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007337563,"threshold_uncertainty_score":0.02454662,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07319296200780288,"score_gpt":0.4131517652719811,"score_spread":0.3399588032641782,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}