{"id":"W4417015986","doi":"10.1182/blood-2025-1748","title":"Non-invasive detection and classification of lymphoma via cell-free DNA methylation profiling","year":2025,"lang":"en","type":"article","venue":"Blood","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vector Institute; Ontario Institute for Cancer Research; University of Toronto; Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"DNA methylation; Lymphoma; CpG site; Methylation; Follicular lymphoma; Diffuse large B-cell lymphoma; DNA; Predictive value","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001207178,0.0003523671,0.0004260499,0.001098291,0.0001190308,0.0007222625,0.0004127403,0.0004270021,0.0009527444],"category_scores_gemma":[0.002031237,0.000199306,0.0003083822,0.0003148813,0.0002127362,0.0002920041,0.000420151,0.0004557247,0.000421834],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003447112,"about_ca_system_score_gemma":0.0002052927,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002021353,"about_ca_topic_score_gemma":0.002855444,"domain_scores_codex":[0.9993918,0.0002075154,0.00003631748,0.0001771443,0.0001261569,0.00006099692],"domain_scores_gemma":[0.9992028,0.0003769829,0.0001520368,0.0001108382,0.0001094543,0.00004800577],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001860598,0.0001907891,0.6654309,0.0001844459,0.0003259989,0.0002331363,0.0001826067,0.007884924,0.1989149,0.0003590358,0.001118332,0.1233143],"study_design_scores_gemma":[0.0001186125,0.0008696929,0.5724765,0.00007343301,0.0003382768,0.001256207,0.0002313255,0.2779779,0.1406009,0.00232884,0.003664717,0.00006347629],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9653552,0.001077718,0.03061751,0.000102144,0.00001740242,0.0000991845,0.001534296,0.0003497656,0.0008468572],"genre_scores_gemma":[0.9905461,0.0001545073,0.007502401,0.00004969045,0.00001442559,0.00003941134,0.001165683,0.00001538213,0.0005124821],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002021353,"threshold_uncertainty_score":0.006384194,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006133005915640979,"score_gpt":0.2202393451451168,"score_spread":0.2141063392294758,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}