{"id":"W4417016148","doi":"10.1182/blood-2025-1438","title":"A zebrafish model of parn deficiency identifies altered lipid metabolism as a novel therapeutic target for restoring hematopoiesis in dyskeratosis congenita","year":2025,"lang":"en","type":"article","venue":"Blood","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; AGADA Biosciences; Hospital for Sick Children; University of Ottawa; Agricultural Research Institute of Ontario","funders":"","keywords":"Dyskeratosis congenita; Zebrafish; Cytopenia; Bone marrow failure; Hematopoietic stem cell; Bone marrow; Myeloid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001161252,0.0001160528,0.0001845759,0.00008167919,0.00005365624,0.00002029891,0.0001331369,0.0001159011,0.00000389064],"category_scores_gemma":[0.0000751008,0.0001125788,0.00009774865,0.000124635,0.00003554253,0.000006329649,0.00005576435,0.00005168976,5.642441e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004854062,"about_ca_system_score_gemma":0.0000684294,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002151307,"about_ca_topic_score_gemma":0.00003922296,"domain_scores_codex":[0.9992519,0.0000172157,0.0002272765,0.0002580576,0.0000772192,0.0001683507],"domain_scores_gemma":[0.9995624,0.00001386536,0.00006754382,0.0002540529,0.00008010973,0.00002206624],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009259235,0.0001583302,0.0007402746,0.00007205227,0.0001005992,1.39075e-7,0.0001124784,0.0001403989,0.9955041,0.002745421,0.0001065986,0.0002269466],"study_design_scores_gemma":[0.001992,0.0001075871,0.001494835,0.00002627109,0.0001676007,0.000003485567,0.000142323,0.0006521216,0.9901708,0.003105542,0.001977496,0.0001599248],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902638,0.001651873,0.006724358,0.00006350533,0.0002553822,0.0002426396,0.00002704618,0.000009966716,0.0007614703],"genre_scores_gemma":[0.9969317,0.00005145695,0.002363659,0.0001297547,0.0000785193,0.00005168342,0.0000212148,0.00001502902,0.0003570239],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006667901,"threshold_uncertainty_score":0.4590829,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01325567469088018,"score_gpt":0.2475588306561665,"score_spread":0.2343031559652863,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}