{"id":"W4417016543","doi":"10.1182/blood-2025-5524","title":"A first-in-human Phase 1 trial of LY4152199, a B-cell activation factor receptor (BAFF-R) T-cell engager bispecific antibody, in patients with previously treated B-cell malignancies (BAF_FRontier-1 Trial in Progress)","year":2025,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Lymphoma; Follicular lymphoma; Dosing; Macroglobulinemia; In vivo; Antibody; Waldenstrom macroglobulinemia; Chronic lymphocytic leukemia; Toxicity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001415926,0.002076314,0.001358705,0.0003204287,0.0005592768,0.001361773,0.0009618724,0.001901187,0.006784359],"category_scores_gemma":[0.000609028,0.0004969292,0.0009146873,0.0002781206,0.0007776446,0.001263484,0.0005160646,0.004216096,0.001676999],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001011386,"about_ca_system_score_gemma":0.001515485,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006608095,"about_ca_topic_score_gemma":0.002009982,"domain_scores_codex":[0.9996198,0.0001621612,0.00001362354,0.00006629628,0.00003695501,0.0001011455],"domain_scores_gemma":[0.9995365,0.00006702364,0.00007708504,0.00003403161,0.00003323659,0.0002521495],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5425254,0.1166238,0.006488597,0.001708408,0.00168536,0.0007899434,0.0005913647,0.003895774,0.1211341,0.001200336,0.0284474,0.1749096],"study_design_scores_gemma":[0.4403773,0.5256809,0.007146951,0.00007311675,0.000374173,0.0007308284,0.00009336181,0.001469952,0.01169314,0.000675315,0.01163474,0.00005029445],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9754164,0.003827234,0.001834291,0.001644627,0.00029067,0.006229027,0.00454113,0.0003850307,0.005831624],"genre_scores_gemma":[0.9633212,0.002832573,0.004228981,0.002867354,0.0002975336,0.006506692,0.008918427,0.000125261,0.01090196],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006784359,"threshold_uncertainty_score":0.0226959,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01915229550309165,"score_gpt":0.3054124579778464,"score_spread":0.2862601624747548,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}