{"id":"W4417016716","doi":"10.1182/blood-2025-52","title":"EZH2 and CREBBP mutation status identify a subset of patients who benefit from bendamustine- over CHOP/CVP-based immunochemotherapies in follicular lymphoma: Findings from the GALLIUM trial and validation in a large international cohort","year":2025,"lang":"en","type":"article","venue":"Blood","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Bendamustine; Obinutuzumab; Cohort; Rituximab; Follicular lymphoma; Chemoimmunotherapy; Clinical trial; Proportional hazards model","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001298631,0.000339881,0.000398141,0.0002042678,0.0002031047,0.0007105237,0.0003502549,0.0004861514,0.001687711],"category_scores_gemma":[0.0013555,0.0001655413,0.0006657122,0.000303302,0.0003812071,0.0003799445,0.0003779684,0.000830724,0.0002908985],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004274071,"about_ca_system_score_gemma":0.0002823241,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005934502,"about_ca_topic_score_gemma":0.001460457,"domain_scores_codex":[0.9996044,0.0001612184,0.0000268198,0.0001057247,0.00004540664,0.00005650054],"domain_scores_gemma":[0.9993713,0.0001516917,0.0001753065,0.0001003507,0.00005342498,0.0001479268],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.1077159,0.001158953,0.8152363,0.0002323214,0.002057686,0.000277942,0.0002710864,0.001126165,0.02083196,0.0003159766,0.003016932,0.0477588],"study_design_scores_gemma":[0.01568658,0.01239666,0.9511599,0.0000902526,0.002721033,0.001351405,0.0002972707,0.002712672,0.005627369,0.0008307702,0.007070758,0.00005533766],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979753,0.0006229566,0.0001203029,0.0001219597,0.00001121349,0.0000422924,0.000464339,0.00000522292,0.0006365099],"genre_scores_gemma":[0.99845,0.00009182401,0.0001803886,0.0001504579,0.00001907837,0.00003442682,0.0008863221,0.000002850301,0.0001845518],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001687711,"threshold_uncertainty_score":0.006867945,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005904439077180711,"score_gpt":0.2568182194952061,"score_spread":0.2509137804180254,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}