{"id":"W4417016977","doi":"10.1182/blood-2025-3315","title":"Identification of XPO1 interactors and modulation by selinexor in diffuse large B cell lymphoma","year":2025,"lang":"en","type":"article","venue":"Blood","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada; Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"","keywords":"Biotinylation; Diffuse large B-cell lymphoma; Lymphoma; Proteomics; Venetoclax; Mitochondrion; Biotin; Identification (biology); Cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004666531,0.00004470141,0.00004989812,0.00003430407,0.00001372199,0.000007053742,0.00003323428,0.00006355929,0.000001835517],"category_scores_gemma":[0.00001818406,0.00004403291,0.0000157343,0.00005348773,0.000009508255,0.000002993933,0.00002476229,0.00001706042,6.025161e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000002866854,"about_ca_system_score_gemma":0.00000787628,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001064153,"about_ca_topic_score_gemma":0.00001572999,"domain_scores_codex":[0.9996559,0.00001554116,0.0001269366,0.0001212141,0.00002810054,0.00005231106],"domain_scores_gemma":[0.9998137,0.00000332501,0.00004508115,0.000105725,0.00002209024,0.0000101033],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002165926,0.000470065,0.01340351,0.00002117838,0.000009875816,1.163404e-7,0.00003375651,0.000001053736,0.984048,0.00003261118,0.0003741024,0.001584091],"study_design_scores_gemma":[0.003770879,0.00004809485,0.0839541,0.000009117902,0.00002273839,9.426766e-7,0.00005402884,0.0003109987,0.9076644,0.0000888943,0.00401249,0.00006336164],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986992,0.0002991843,0.0006657898,0.00002458529,0.00007598392,0.00005808972,0.00001348942,0.000003196514,0.0001604574],"genre_scores_gemma":[0.9994144,0.00006196435,0.0000425356,0.00004338058,0.00002050597,0.000002665987,0.00007875256,0.000004343113,0.0003314687],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07638362,"threshold_uncertainty_score":0.179561,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.001851523853129403,"score_gpt":0.2021712708441068,"score_spread":0.2003197469909774,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}