{"id":"W4417017164","doi":"10.1182/blood-2025-3230","title":"Ectopic BCL11B disrupts the activity of early hematopoietic transcription factors to skew lineage commitment","year":2025,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"","keywords":"Ectopic expression; Progenitor cell; Haematopoiesis; Transcription factor; Myeloid; Stem cell; Immunophenotyping; Hematopoietic stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001410557,0.0002641177,0.0001335096,0.0002011591,0.0001353762,0.0003651597,0.000175787,0.0002289747,0.001731155],"category_scores_gemma":[0.00009366459,0.000187951,0.0001455576,0.000167971,0.0002603383,0.0001474759,0.0002834577,0.0007011991,0.0004564653],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002679402,"about_ca_system_score_gemma":0.0001630203,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004792828,"about_ca_topic_score_gemma":0.0006573867,"domain_scores_codex":[0.9997745,0.00003617284,0.00003169146,0.00004654325,0.00005783646,0.00005325472],"domain_scores_gemma":[0.9997752,0.00006100962,0.00005002078,0.00003479401,0.00001301456,0.00006586868],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003558099,0.00001432989,0.00009025065,0.000007876439,0.000001070483,0.00001606458,0.000005903975,0.00003010888,0.9995099,0.00006217678,0.000007901514,0.0002187819],"study_design_scores_gemma":[0.000006707515,0.00007645133,0.001391067,0.000002465534,0.000003675639,0.0001048419,0.00001802273,0.0007660607,0.9966953,0.00001841585,0.000915757,0.000001301462],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956905,0.0003804089,0.002489556,0.0000447267,0.00001701866,0.00002648696,0.0003522822,0.00008811725,0.0009110364],"genre_scores_gemma":[0.9966515,0.000182004,0.001093838,0.00002581021,0.000003558025,0.00002044117,0.0002788933,0.00003102955,0.001713059],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001731155,"threshold_uncertainty_score":0.005791306,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02441566895304176,"score_gpt":0.3122934303938841,"score_spread":0.2878777614408423,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}