{"id":"W4417017886","doi":"10.1182/blood-2025-698","title":"Efficacy and safety of talquetamab + teclistamab in patients with Relapsed/Refractory multiple myeloma and extramedullary disease: Updated Phase 2 results from the redirectt-1 study with extended follow-up","year":2025,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Alberta Health; Alberta Health Services","funders":"","keywords":"Multiple myeloma; Cohort; Phases of clinical research; Plasmacytoma; Progressive disease; Cancer; Soft tissue; Bone marrow","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002202302,0.0003996725,0.001019076,0.0003345595,0.0001647376,0.0007938399,0.0004438865,0.0003453518,0.001028725],"category_scores_gemma":[0.001283412,0.0001931364,0.0011323,0.0004541009,0.0001896919,0.0004869769,0.0003250104,0.0008582993,0.0002617173],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006237125,"about_ca_system_score_gemma":0.0004726816,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005344595,"about_ca_topic_score_gemma":0.001549647,"domain_scores_codex":[0.9994007,0.0002593791,0.00005450435,0.00009975732,0.0001286165,0.00005706655],"domain_scores_gemma":[0.9988868,0.0002215514,0.0005011077,0.00008954261,0.000125772,0.0001753659],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.2715386,0.006683685,0.3000133,0.00236587,0.01257974,0.0004476442,0.0004294226,0.007887718,0.03988191,0.0003320549,0.01095594,0.3468841],"study_design_scores_gemma":[0.09107183,0.1273388,0.7358738,0.0002579217,0.009777196,0.001861669,0.0001573418,0.00695391,0.01129752,0.0004781982,0.01482516,0.0001066019],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897448,0.005697926,0.0005020163,0.000247546,0.00003033829,0.0002515374,0.002075199,0.00006395795,0.001386704],"genre_scores_gemma":[0.9936959,0.001089889,0.000519465,0.0003553315,0.00005781028,0.0001768704,0.003587356,0.00001163973,0.0005056947],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002202302,"threshold_uncertainty_score":0.01164705,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009697505005120908,"score_gpt":0.2670396022867548,"score_spread":0.2573420972816339,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}