{"id":"W4417018334","doi":"10.1182/blood-2025-4810","title":"Effectiveness of sirolimus for pediatric autoimmune cytopenias and factors associated with clinical response","year":2025,"lang":"en","type":"article","venue":"Blood","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital; Hospital for Sick Children","funders":"","keywords":"Sirolimus; Eltrombopag; Thrombopoietin receptor; Tacrolimus; Immune system; Immunosuppression; Mycophenolic acid; Everolimus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006529976,0.000130325,0.0002860661,0.0006874186,0.0002502533,0.0004378131,0.0002041989,0.0001409807,0.001595693],"category_scores_gemma":[0.002195512,0.0000469699,0.0003144428,0.0009284822,0.0002224123,0.0002045145,0.0001191879,0.0002470043,0.000102046],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002104448,"about_ca_system_score_gemma":0.001831171,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02734931,"about_ca_topic_score_gemma":0.04081312,"domain_scores_codex":[0.9994468,0.0001225326,0.00009113126,0.00006597968,0.0001695309,0.0001040338],"domain_scores_gemma":[0.9972051,0.0006098335,0.00133607,0.00003454062,0.0004332825,0.000381124],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003658129,0.0000181467,0.989944,0.00007986179,0.00003033245,0.0005441644,0.00007208577,0.0001303421,0.0003184753,0.00003953547,0.0006144706,0.007842726],"study_design_scores_gemma":[0.00001695618,0.0002015132,0.9955166,0.00006520604,0.0000568317,0.001871728,0.0001882527,0.0002366417,0.0004225989,0.00001228984,0.001407326,0.000003983991],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9856383,0.008383879,0.0001122117,0.0003942842,0.00001653008,0.00005560879,0.001365304,0.00001786552,0.004015921],"genre_scores_gemma":[0.9980447,0.001081314,0.0001516033,0.000071558,0.00001511762,0.00001425164,0.0004620953,0.000001873591,0.0001575316],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02734931,"threshold_uncertainty_score":0.05438024,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01536729453893896,"score_gpt":0.2764192470858835,"score_spread":0.2610519525469445,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}