{"id":"W4417019462","doi":"10.1182/blood-2025-3559","title":"Spatial profiling of the bone marrow microenvironment in patients with IgM gammopathies reveals a T cell–Enriched tumor niche associated with asymptomatic waldenstrom macroglobulinemia progression","year":2025,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Integrity Testing Laboratory (Canada)","funders":"","keywords":"Waldenstrom macroglobulinemia; Monoclonal gammopathy of undetermined significance; Multiple myeloma; Bone marrow; Asymptomatic; Macroglobulinemia; Immunoglobulin M; Monoclonal","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002350087,0.0002041216,0.000198288,0.001184965,0.0002309848,0.0005074232,0.0001702152,0.0002296457,0.0009141602],"category_scores_gemma":[0.0004087756,0.0001366104,0.00018815,0.0006575559,0.0001740262,0.0001949523,0.0003205803,0.0001413845,0.000219359],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001729928,"about_ca_system_score_gemma":0.0001034127,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001425387,"about_ca_topic_score_gemma":0.001675273,"domain_scores_codex":[0.9998587,0.00002556129,0.0000136655,0.00004342498,0.00002644515,0.00003210127],"domain_scores_gemma":[0.9998124,0.00002898923,0.00008127284,0.00001497227,0.00003054319,0.00003183786],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005934473,0.00002918488,0.9129925,0.00004606312,0.00008021141,0.0007422256,0.000156116,0.000392857,0.07509879,0.00009048088,0.0002669375,0.009511204],"study_design_scores_gemma":[0.000007367433,0.00006703017,0.9904918,0.000008514562,0.00003447948,0.001522635,0.0002385884,0.001531982,0.005633623,0.0001028133,0.0003561275,0.000005029465],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989163,0.0003268461,0.0003577628,0.00001673681,0.000001525638,0.000002757788,0.0001546375,0.00001416632,0.0002093931],"genre_scores_gemma":[0.9994032,0.0000569541,0.0003273097,0.0000100998,0.00000373701,0.000003135674,0.0001249312,0.000002543869,0.00006817989],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001425387,"threshold_uncertainty_score":0.003058136,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004096862065782521,"score_gpt":0.2237807102719181,"score_spread":0.2196838482061356,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}