{"id":"W4417019469","doi":"10.1182/blood-2025-1288","title":"Concizumab efficacy in patients with Hemophilia A/B without inhibitors from the Phase 3 explorer8 study: A post-hoc sensitivity analysis for the intra-patient comparison of concizumab with previous prophylaxis","year":2025,"lang":"en","type":"article","venue":"Blood","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster Children's Hospital","funders":"","keywords":"Confidence interval; Antibody; Phases of clinical research; Pooled analysis; Incidence (geometry); Monoclonal antibody; Monoclonal","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02989769,0.001792269,0.004592427,0.0005959527,0.0003626632,0.001790888,0.001369286,0.001618673,0.00470934],"category_scores_gemma":[0.0231736,0.0007113618,0.0153899,0.0005729481,0.0007970257,0.001098979,0.001025732,0.002855915,0.0003780588],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005986294,"about_ca_system_score_gemma":0.0007367999,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005530627,"about_ca_topic_score_gemma":0.0008016595,"domain_scores_codex":[0.9706617,0.02324999,0.001051808,0.002691043,0.001470848,0.0008746616],"domain_scores_gemma":[0.9573734,0.03546196,0.002591198,0.003141015,0.0007495566,0.000682916],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7239206,0.001236268,0.06349422,0.002810369,0.1795976,0.000678803,0.0002623991,0.005898589,0.00601246,0.0005153897,0.001952997,0.01362029],"study_design_scores_gemma":[0.1106555,0.1456884,0.3524377,0.0005457763,0.3269824,0.001876373,0.000451439,0.03829934,0.009482438,0.00221279,0.01095397,0.0004138101],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9765052,0.01249413,0.004434853,0.0002293681,0.0003725291,0.001098968,0.002430829,0.0001034862,0.002330677],"genre_scores_gemma":[0.9950518,0.0004406073,0.001453227,0.0002630038,0.0001091662,0.0007399933,0.001192733,0.00004758305,0.0007020023],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02989769,"threshold_uncertainty_score":0.158116,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01950554457668843,"score_gpt":0.312663162758121,"score_spread":0.2931576181814326,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}