{"id":"W4417019768","doi":"10.1182/blood-2025-2302","title":"Trial in progress: QUINTESSENTIAL-2—a phase 3 study of arlocabtagene autoleucel versus standard of care in adult patients with relapsed and refractory multiple myeloma (RRMM) exposed to lenalidomide","year":2025,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Maisonneuve-Rosemont","funders":"","keywords":"Lenalidomide; Multiple myeloma; Clinical trial; Refractory (planetary science); Phases of clinical research; Pomalidomide; Adverse effect; Standard of care","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002095044,0.001531055,0.002082853,0.0003970757,0.0004789915,0.001441011,0.00117451,0.002011231,0.007136107],"category_scores_gemma":[0.001109638,0.0004785171,0.002112244,0.0003824299,0.0009587612,0.001120321,0.0004350021,0.004930938,0.001326001],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009111037,"about_ca_system_score_gemma":0.001174508,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001158592,"about_ca_topic_score_gemma":0.002801179,"domain_scores_codex":[0.9994647,0.0002740206,0.00002293007,0.00008530304,0.00004623926,0.0001069404],"domain_scores_gemma":[0.9991285,0.0001355859,0.0001625266,0.00006432317,0.00006568566,0.0004433531],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.901611,0.03341963,0.002672895,0.0006302238,0.001393179,0.0001211592,0.0001674325,0.0009073068,0.008549356,0.0002380733,0.004511086,0.0457787],"study_design_scores_gemma":[0.7856027,0.2050042,0.005542798,0.00003600395,0.0002912549,0.0001282791,0.00004585658,0.0007077825,0.0007651183,0.0001955332,0.001658079,0.00002233469],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.9800457,0.006062179,0.0006633713,0.002026108,0.0004499588,0.003679656,0.003672776,0.0002544528,0.003145825],"genre_scores_gemma":[0.976971,0.002770754,0.002009042,0.003113214,0.0004738226,0.003810872,0.004486469,0.00005922718,0.006305644],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.007136107,"threshold_uncertainty_score":0.02387267,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01560916056472494,"score_gpt":0.3174020874040857,"score_spread":0.3017929268393607,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}