{"id":"W4417020547","doi":"10.1182/blood-2025-6959","title":"Oral n-myristoyltransferase inhibitor zelenirstat for adults with Relapsed/Refractory Acute Myeloid Leukemia (AML): A phase 1 trial in progress","year":2025,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Achieve Life Sciences (Canada)","funders":"","keywords":"Venetoclax; Pharmacokinetics; Pharmacodynamics; Myeloid leukemia; Clinical trial; Leukemia; CYP3A; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001879476,0.001082487,0.001392595,0.0003598236,0.0002865037,0.0008028483,0.0007217323,0.0008664902,0.003495452],"category_scores_gemma":[0.0006675664,0.000303387,0.001043011,0.0003417784,0.0005471326,0.0007224652,0.000313525,0.002435047,0.0007207237],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005712503,"about_ca_system_score_gemma":0.001446401,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006594805,"about_ca_topic_score_gemma":0.002245004,"domain_scores_codex":[0.9996692,0.0001775502,0.00001905589,0.00004382283,0.00003351439,0.00005686075],"domain_scores_gemma":[0.9995425,0.00009094342,0.0001067369,0.00003621373,0.00003445186,0.0001891754],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6249303,0.04795737,0.006787177,0.001708371,0.002130365,0.0002554661,0.0003059919,0.005306114,0.0621605,0.0005891967,0.008819452,0.2390499],"study_design_scores_gemma":[0.6039473,0.3696712,0.01032265,0.0000825657,0.0007029183,0.0003043751,0.00007031319,0.002491423,0.005660194,0.0004456118,0.006267403,0.00003402855],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.9817734,0.005981781,0.001809579,0.001305199,0.0001315995,0.003789541,0.002207936,0.0002392094,0.002761819],"genre_scores_gemma":[0.97493,0.005356873,0.005827663,0.001630132,0.0002023389,0.004109106,0.003964555,0.00005951851,0.003919729],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.003495452,"threshold_uncertainty_score":0.01169348,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01353743526896165,"score_gpt":0.3110534188332085,"score_spread":0.2975159835642469,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}