{"id":"W4417020824","doi":"10.1182/blood-2025-907","title":"Safety and efficacy of bromodomain and extra-terminal protein inhibitor INCB057643 monotherapy in patients with relapsed or refractory myelofibrosis and other advanced myeloid neoplasms: A phase 1 study","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; McGill University; Bell (Canada); Princess Margaret Cancer Centre","funders":"","keywords":"Myelofibrosis; Bone marrow; Phases of clinical research; Myeloproliferative neoplasm; Anemia; Clinical endpoint; Bromodomain; Refractory (planetary science); Myeloid; Hypomethylating agent","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001182988,0.001160777,0.002173082,0.0003373073,0.0003543771,0.0009712161,0.0007182036,0.001147913,0.002542033],"category_scores_gemma":[0.0005617443,0.0004311863,0.001174708,0.0003527248,0.0005857091,0.0006531267,0.0002555046,0.002579797,0.0008668772],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008208108,"about_ca_system_score_gemma":0.001184578,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005068014,"about_ca_topic_score_gemma":0.001702232,"domain_scores_codex":[0.9996828,0.0001299767,0.00001897635,0.0000628113,0.00004416853,0.00006130106],"domain_scores_gemma":[0.9995,0.00006913951,0.0001125653,0.00003580663,0.0000409745,0.0002413935],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6104377,0.08522326,0.01437922,0.002219806,0.003204676,0.0007583992,0.0005327409,0.004477298,0.1022555,0.0004352822,0.005685071,0.1703911],"study_design_scores_gemma":[0.4052249,0.5535631,0.02763034,0.0001008231,0.0008927317,0.0008443529,0.00009148714,0.00193159,0.00539394,0.0002257133,0.004038453,0.00006257389],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939599,0.002746897,0.0002616446,0.0002325407,0.00005020626,0.000895641,0.0007163601,0.00005905202,0.001077775],"genre_scores_gemma":[0.9928174,0.001590827,0.001003222,0.000711313,0.00008725459,0.0008363501,0.001419872,0.00001773356,0.001516111],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002542033,"threshold_uncertainty_score":0.008503914,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006054009545463277,"score_gpt":0.2435824671873341,"score_spread":0.2375284576418708,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}