{"id":"W4417021249","doi":"10.1182/blood-2025-5785","title":"The evolution to hepta-refractory myeloma involves sequential loss of CD38, BCMA and GPRC5D","year":2025,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Deutsche Krebshilfe; Bundesministerium für Bildung und Forschung","keywords":"Multiple myeloma; Malignancy; Carfilzomib; Proteasome inhibitor; Bortezomib; Hematologic malignancy; Proteasome; Immunohistochemistry; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002169239,0.0002016628,0.000233832,0.0005112847,0.0005259294,0.0004802897,0.0001852376,0.0002259465,0.001903894],"category_scores_gemma":[0.0003396018,0.0001196442,0.0002196738,0.0005101677,0.0002653239,0.0001846798,0.0003647461,0.0002925213,0.0003234846],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000398889,"about_ca_system_score_gemma":0.0001888399,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001491196,"about_ca_topic_score_gemma":0.001719942,"domain_scores_codex":[0.9998373,0.00001541321,0.00001657908,0.00006353104,0.00002901883,0.00003816163],"domain_scores_gemma":[0.9998068,0.00002919058,0.00007458599,0.00002458572,0.00002336791,0.00004146675],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001170572,0.00009659504,0.8704411,0.00007026929,0.00009514137,0.009509403,0.0003473437,0.0007515343,0.09052697,0.000295807,0.001012958,0.02568228],"study_design_scores_gemma":[0.00004847751,0.0003798442,0.9441937,0.000016502,0.0001052326,0.03625293,0.0003864684,0.001736086,0.01375482,0.0003366324,0.002777122,0.00001212211],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980686,0.0001668192,0.0002842782,0.0000464376,0.000001859652,0.00001266293,0.0003822989,0.00001889043,0.001018087],"genre_scores_gemma":[0.9990026,0.00005411854,0.0002430053,0.00003999302,0.00000331491,0.000006815031,0.0003997443,0.00000533578,0.0002450584],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001903894,"threshold_uncertainty_score":0.006369174,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01616384106742638,"score_gpt":0.3010828026486136,"score_spread":0.2849189615811872,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}