{"id":"W4417021874","doi":"10.1182/blood-2025-1608","title":"Clinical, cytogenetic and molecular characteriszation of Mecom- rearranged pediatric de novo Acute Myeloid Leukemia (AML): A retrospective cohort study of the international-berlin-frankfurt-Münster (I-BFM) AML-study group","year":2025,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Retrospective cohort study; Myeloid leukemia; Leukemia; Acute promyelocytic leukemia; Chemotherapy regimen; Cohort; Myeloid; Myeloid sarcoma; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006049965,0.0003254352,0.0003904475,0.0008698829,0.0003695512,0.0005876827,0.0003762433,0.0002596316,0.001010216],"category_scores_gemma":[0.001029682,0.0003186326,0.0002848192,0.001044762,0.0002483414,0.0005548299,0.000522343,0.0003528318,0.0002346234],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000377796,"about_ca_system_score_gemma":0.0004469749,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003432017,"about_ca_topic_score_gemma":0.003472007,"domain_scores_codex":[0.9995605,0.00006903668,0.00004548765,0.0001648249,0.00007345119,0.00008667633],"domain_scores_gemma":[0.9992222,0.00009897719,0.0003308263,0.00009673317,0.00007030967,0.000181032],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00007001786,0.00001751061,0.999023,0.000003066411,0.0000135679,0.0001211132,0.00004167813,0.00001706577,0.0001806581,0.00001216093,0.00004220933,0.0004579638],"study_design_scores_gemma":[0.00001593616,0.000185201,0.9971591,0.000006340985,0.00003234795,0.001643433,0.0002666999,0.0001345561,0.0001599324,0.00001506283,0.000377281,0.000003970252],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999289,0.00009856463,0.00005838341,0.000007128588,0.000001643188,0.00001193774,0.0003640798,0.000001801504,0.0001673207],"genre_scores_gemma":[0.9989612,0.00009728949,0.0000789828,0.00001157213,0.000005211623,0.00001792057,0.0007549008,0.000002022268,0.00007087289],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003432017,"threshold_uncertainty_score":0.006824076,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01225829498684319,"score_gpt":0.3076906259428016,"score_spread":0.2954323309559584,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}