{"id":"W4417022382","doi":"10.1182/blood-2025-4143","title":"First-in-human study of CTX130, a CD70-directed allogeneic CAR T therapy, in adult T-cell leukemia/lymphoma: Clinical and genomics findings from a long-term follow-up of subgroup analysis from the cobalt-LYM Phase 1 trial","year":2025,"lang":"en","type":"article","venue":"Blood","topic":"T-cell and Retrovirus Studies","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Fludarabine; Cyclophosphamide; Clinical endpoint; Clinical trial; Survival analysis; Malignancy; Subgroup analysis; Lenalidomide; Dosing","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004116235,0.0002918199,0.001256041,0.0002603686,0.0001731247,0.00001282579,0.0004262856,0.0003754131,0.00004083306],"category_scores_gemma":[0.0001141966,0.000209923,0.0003278957,0.0005993397,0.0003889231,0.00002892996,0.000231619,0.000279432,0.000002680913],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005341479,"about_ca_system_score_gemma":0.0001317522,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.01662642,"about_ca_topic_score_gemma":0.04968617,"domain_scores_codex":[0.9973027,0.0005879849,0.001141141,0.000589058,0.00006529102,0.00031383],"domain_scores_gemma":[0.9981401,0.0009240213,0.0003259672,0.000505492,0.00008217557,0.00002224448],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01152614,0.007727223,0.897153,0.00001479822,0.005775732,0.00002069473,0.004568927,0.000003434187,0.07245886,0.000007070082,0.00005675694,0.0006873845],"study_design_scores_gemma":[0.2727242,0.001759923,0.703162,0.00004942821,0.002528548,6.354227e-7,0.001457459,0.000007645571,0.0180263,0.00003421473,0.0000367864,0.000212899],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900234,0.008284792,0.0000036124,0.00002447755,0.0004182238,0.0009387649,0.0002443635,0.00002576916,0.00003657385],"genre_scores_gemma":[0.9978734,0.001679365,0.00001421534,0.00004866212,0.00003853571,0.00005759501,0.0001352052,0.00001466201,0.0001383685],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.261198,"threshold_uncertainty_score":0.9899219,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0184909170257456,"score_gpt":0.2819544354967021,"score_spread":0.2634635184709565,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}