{"id":"W4417022382","doi":"10.1182/blood-2025-4143","title":"First-in-human study of CTX130, a CD70-directed allogeneic CAR T therapy, in adult T-cell leukemia/lymphoma: Clinical and genomics findings from a long-term follow-up of subgroup analysis from the cobalt-LYM Phase 1 trial","year":2025,"lang":"en","type":"article","venue":"Blood","topic":"T-cell and Retrovirus Studies","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Fludarabine; Cyclophosphamide; Clinical endpoint; Clinical trial; Survival analysis; Malignancy; Subgroup analysis; Lenalidomide; Dosing","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002562975,0.0006652283,0.001192579,0.000241579,0.0004757938,0.001400879,0.0004520583,0.0007445861,0.001868575],"category_scores_gemma":[0.001651951,0.0002482526,0.001568192,0.0003969754,0.0007561219,0.0006043576,0.0004319913,0.00120098,0.0003315355],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001111859,"about_ca_system_score_gemma":0.001067466,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009204745,"about_ca_topic_score_gemma":0.002378189,"domain_scores_codex":[0.9989603,0.0004490365,0.00007199749,0.000216559,0.0001170849,0.0001850117],"domain_scores_gemma":[0.9984087,0.0002849593,0.0005112248,0.0002266708,0.0001297838,0.0004387262],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6464072,0.009434656,0.1861233,0.001167593,0.01327486,0.0005696522,0.0006095932,0.002988746,0.04256113,0.0004679142,0.005583942,0.09081136],"study_design_scores_gemma":[0.164841,0.3280089,0.4532703,0.0001810577,0.01692266,0.001880032,0.0005667523,0.003602427,0.01642671,0.001121143,0.01302342,0.0001557036],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953478,0.001701289,0.0003672414,0.0002141167,0.00002934393,0.0003440008,0.001101037,0.00002675056,0.0008685477],"genre_scores_gemma":[0.9963056,0.0003806693,0.0002766858,0.0002596403,0.00005372907,0.0002323533,0.001754085,0.00001113572,0.0007262041],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002562975,"threshold_uncertainty_score":0.01355445,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0184909170257456,"score_gpt":0.2819544354967021,"score_spread":0.2634635184709565,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}